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A Novel Synthesis of 3-Amino-1,2-benzisoxazoles – an Entry into the Isoxazolo<3,4,5-ef><1,4>benzoxazepine Ring System

A novel synthesis of 3-amino-1,2-benzisoxazole (3) from 2-<(isopropylideneamino)oxy>benzonitrile (2) is described.This methodology was used to synthesize 3-amino-4-hydroxy-1,2-benzisoxazole (10), which served as an intermediate for a number of isoxazolo<3,4,5-ef><1,4>benzoxazepines.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Synthesis of trans-7-Hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyrido<1,2-a>pyrazine

An efficient synthesis of trans-7-hydroxymethyl-2-(2-benzisoxazol-3-yl)octahydro-2H-pyrido<1,2-a>pyrazine 2 is presented which relies on the equilibration of cis-dimethyl piperidinedicarboxylate followed by alkylation with phthalimidoethyl triflate.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Dental adhesive composition

A dental adhesive composition which can quickly be hardened even in the presence of oxygen without using a radical generating agent such as a peroxide or a photopolymerization initiator, to give high bond strength, the composition including, in specific amounts, (A) a carboxylic acid compound having a (meth)-acryloyl group and a carboxyl group, both of which are attached to an aromatic ring; (B) a bisphenol A derivative having two (meth) acryloyl groups; (C) a hydroxylalkyl (meth)acrylate; (D) a (meth)acrylate derivative having an acid group; and (E) at least one polymerization initiator selected from the group consisting of aromatic amines, aliphatic amines, and aromatic sulfinic acids; the composition being substantially free from any radical polymerization initiator.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Related Products of 66033-92-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.66033-92-9, Name is 3-Methyl-1,2-benzisoxazol-6-ol, molecular formula is C8H7NO2. In a Patent£¬once mentioned of 66033-92-9

5-Thioxylopyranose Compounds

5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-beta-D-xylopyranosyl group; R?, R? and R?? each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a ?COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Indoline -1H- pyrazolo [3,4-d] pyrimidinone compound, as well as preparation method and application thereof (by machine translation)

The present invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt, thereof, which may be better selective Wee1 as a new generation, selective inhibitor Wee1 with respect to the existing, inhibitor Wee1 for, Kinase more safe and higher treatment index, and thus has better safety and broader application range, for treatment, of various tumors including brain tumors. (by machine translation)

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Final Thoughts on Chemistry for Benzo[d]isoxazol-3-ol

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Ortho Effects in Shiff Bases of Diaminodicyanoethane

In the electron impact mass spectra of azomethines derived from various substituted aromatic aldehydes and diaminodicyanoethene the superposition of two ortho effects concurring with the azomethine group is apparent: one involving the amino group of the diaminodicyanoethene part accounts for the cyclization to + ions and the other involving ortho substituents of the benzylidene part which can interact with the azomethine moiety is responsible for specific fragment ions, suppressing the typical fragmentations of azomethines.The ortho effect was studied for the o-nitro derivative by labelling experiments, analysis of metastable transitions and collisional activation comparing model ions, demonstrating that the specific +. and +. ions are the result of cyclization processes.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Reference of 99822-23-8, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 99822-23-8, name is 5-Fluorobenzo[d]isoxazol-3(2H)-one, introducing its new discovery.

Cobalt(III)-Catalyzed Oxadiazole-Directed C-H Activation for the Synthesis of 1-Aminoisoquinolines

Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but can be retained as undesired bulky substituents in the final products. Herein, we report a Co(III)-catalyzed 1-aminoisoquinoline synthesis strategy based on oxadiazole-directed aromatic C-H coupling with alkynes and a subsequent redox-neutral C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of functional groups.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents

Members of the series of title compounds were tested for potential antipsychotic activity in relevant receptor binding assays and behavioral screens.Structure-activity relationships within the series are discussed.Compound 24 (BMY 13859-1), a (1,2-benzisothiazol-3-yl)piperazine derivative, was selected for further study because of its potent and selective profile in primary CNS tests.It was active in the Sidman avoidance paradigm and blocked amphetamine-induced stereotyped behavior in dogs for up to 7 h.The compound’s lack of typical neuroleptic-like effects in therat catalepsy test and its failure to produce dopamine receptor supersensitivity following chronic administration indicate that it should not cause the movement disorders commonly associated with antipsychotic therapy.Although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile.Compound 24 is currently undergoing clinical evaluation in schizophrenic patients.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Photochemistry of 3-amino-1,2-benzisoxazole: unexpected photoisomerization of an amino-spiro-2H-azirine to a 1H-diazirine

UV irradiation of 3-amino-1,2-benzisoxazole isolated in an argon matrix leads to the formation of an amino-spiro-2H-azirine. The amino-spiro-2H-azirine was found to photoisomerize back to 3-amino-1,2-benzisoxazole and also to a 1H-diazirine, which isomerizes to a carbodiimide. All the reported species were characterized experimentally by IR spectroscopy and confirmed by comparison with theoretical IR spectra. The discovery of the transformation of an amino-spiro-2H-azirine into a 1H-diazirine is unprecedented in the chemistry of reactive intermediates.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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IMPROVED AND SIMPLIFIED PROCESS FOR THE PREPARATION OF 1,2-BENZISOXAZOLE-3-ACETIC ACID

A process for preparation of 1,2-benzisoxazole-3-acetic acid reacting 4-hydroxy coumarin and hydroxylamine in water according to the following scheme of reaction. Formula (I).

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics