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Muscarinic agonists

Compounds are provided which are useful in the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4 or both m1 and m4, receptor activity has a beneficial effect. Also a use is provided of the compounds in the manufacture of pharmaceutical compositions for treating such diseases and conditions.

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Benzisoxazole – Wikipedia,
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Substituted benzisoxazole and benzisothiazole herbicidal agents

There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I STR1 Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.

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Benzisoxazole – Wikipedia,
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CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF

Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

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Benzisoxazole – Wikipedia,
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Process for the preparation of 6-(perfluoroalkyl) uracil compounds from 2-(N,N-disubstituted) amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds

An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula I STR1 from 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula II STR2

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Benzisoxazole – Wikipedia,
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Bone cement in paste form

A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1), peroxide(s) (a2) and tertiary amine(s) (a3). The paste (B) contains radical polymerizable monomer(s) (b1), heavy metal compound(s) (b2), and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, peroxide(s) (a2) as polymerization initiator, and tertiary amine(s) and/or amidine(s) (a3) as copolymer ion accelerator. The paste (B) contains radical polymerizable monomer(s) (b1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, heavy metal compound(s) (b2) as polymerization accelerator, and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). An independent claim is included for molded product, which is obtained by polymerization of paste obtained by mixing paste (A) and paste (B) of the kit.

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Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(benzo[d]isoxazol-3-ylmethyl)-1H-benzimidazoles

(Chemical Equation Presented) Synthesis of a series of novel class of N-substituted-2-(benzo[d]isoxazol-3-ylmethyl)-1H-benzimidazoles (4) by the condensation of o-phenylenediamine (1) with benzo[d]isoxazol-3-yl-acetic acid (2) and subsequent reactions with different types of electrophiles have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium, however poor activity against Staphylococcus aureus. The compound 4t was found to have high activity even at 1 mug/ml compared to Cephalexin against S. aureus. The biological activity against PDE-IV for potential anti-asthmatic effect and against DP-IV and PTP-1B for potential anti-diabetic effects was disappointing.

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Benzisoxazole – Wikipedia,
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A novel method for the highly efficient synthesis of 1,2-benzisoxazoles under neutral conditions using the Ph3P/DDQ system

The use of Ph3P/DDQ offers a novel, neutral and highly efficient method for the efficient conversion of 2-hydroxyaryl aldoximes and ketoximes to 1,2-benzisoxazoles in excellent yields at room temperature.

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Radiopaque dental materials

Highly esthetic dental compositions have both good radiopacity and optical opacity. It has been found that the addition of bismuth fluoride to dental material compositions provides these desirable properties. Bismuth fluoride is relatively inexpensive and easily obtainable.

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Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R3?, R4, R6, R?, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

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Benzisoxazole – Wikipedia,
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Synthesis of novel benzothiozole and benzisoxazole functionalized unsymmetrical alkanes and of there antimicrobial activity

Novel unsymmetrical alkanes 4 and 5 have been independently synthesized in single pot from 2-amino 5/6hydroxybenzothiazole, 6-hydroxy-3-methyl-l,2- benzisoxazole and different dihaloalkanes [X-(CH2)n-X]. The compounds 4 and 5 have been screened for antimicrobial activity and some of them havefceen found to show promising activity.

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Benzisoxazole – Wikipedia,
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