Some scientific research about Benzo[d]isoxazol-3-amine

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4- [3- (ARYLOXY) BENZYLIDENE] -3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS

The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Can You Really Do Chemisty Experiments About 65685-55-4

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Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 65685-55-4, Name is Benzo[d]isoxazol-6-ol,introducing its new discovery., Formula: C7H5NO2

Bone cement in paste form

A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1), peroxide(s) (a2) and tertiary amine(s) (a3). The paste (B) contains radical polymerizable monomer(s) (b1), heavy metal compound(s) (b2), and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). A kit comprises paste (A) and paste (B). The paste (A) contains radical polymerizable monomer(s) (a1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, peroxide(s) (a2) as polymerization initiator, and tertiary amine(s) and/or amidine(s) (a3) as copolymer ion accelerator. The paste (B) contains radical polymerizable monomer(s) (b1) having boiling point of less than 120[deg] C under pressure of 1.013 mbar, heavy metal compound(s) (b2) as polymerization accelerator, and sulfimide(s) and/or dicarboxylic acid imide(s) (b3) as copolymer ion accelerator. The pastes (A) and (B) contains filler as component (a4) and/or (b4), respectively. The filler is insoluble in radical polymerizable monomer(s) (a1) and/or (b1). An independent claim is included for molded product, which is obtained by polymerization of paste obtained by mixing paste (A) and paste (B) of the kit.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Some scientific research about 1,2-Benzisoxazole-3-acetic Acid

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One-pot process for the preparation of 1,2-benzisoxazole-3-methanesulfonamide

A process for the preparation of 1,2-benzisoxazole-3-methane-sulfonamide without isolation of intermediates in solid form, by using 4-hydroxycoumarin as a starting compound, and water and 1,2-dichloro-ethane as solvents; and an industrially useful process for the preparation of 1,2-benzisoxazole-3-acetic acid, by reacting 4-hydroxycoumarin and hydroxylamine in water.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The Absolute Best Science Experiment for Benzo[d]isoxazol-3-amine

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NEW TRIAZINE DERIVATIVE, ULTRAVIOLET ABSORBER, AND RESIN COMPOSITION

To provide a novel triazine-based compound exhibiting an ultraviolet blocking effect even in the long-wavelength region and being useful as an ultraviolet absorber with excellent light resistance, and to provide an ultraviolet absorber and a resin composition, which can maintain a long-wavelength ultraviolet-blocking effect for a long period of time. A compound represented by the following formula (1): wherein each of R1a, R1b, R1c, R1d and R1e independently represents a hydrogen atom or a monovalent substituent excluding OH, provided that at least one substituent represents a substituent having a Hammett’s sigmap value of 0.3 or more and substituents may combine with each other to form a ring, and each of R1g, R1h, R1i, R1j, R1k, R1m, R1n and R1p independently represents a hydrogen atom or a monovalent substituent, provided that substituents may combine with each other to form a ring.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

New explortion of Benzo[d]isoxazol-3-ol

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1,2-Benzisoxazol-3-yl Diphenyl Phosphate: A New, Reactive Activating Agent for the Synthesis of Amides, Esters, and Peptides via Condensation

A new activating agent for condensations, 1,2-benzisoxazol-3-yl diphenyl phosphate (1), was readily prepared in high yield by the reaction of 1,2-benzisoxazol-3-ol (2) with diphenyl phosphorochloridate (3) in the presence of triethylamine in benzene.The reaction of the carboxylic acids with the amines in the presence of 1 was investigated by two procedures, a two-step method and a one-step procedure.Both methods gave the corresponding amides and esters in high yields under mild conditions, but the one-step procedure was found to be superior to the two-step procedure because of its simplicity and speed.Furthermore, the activating agent 1 was shown to be a useful peptide forming reagent.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Can You Really Do Chemisty Experiments About 3-Chloro-1,2-benzisoxazole

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Synthesis of an Optically Active Octahydro-2H-pyrido<1,2-a>pyrazine Based CNS Agent

A synthesis of an optically active octahydro-2H-pyrido<1,2-a>pyrazine is presented.The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic transaldehyde that was trapped by nitromethane anion.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

More research is needed about 65685-55-4

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65685-55-4, Name is Benzo[d]isoxazol-6-ol, belongs to Benzisoxazole compound, is a common compound. HPLC of Formula: C7H5NO2In an article, once mentioned the new research about 65685-55-4.

Dental compositions

A two part composition for sealing and/or filling root canals. One or more elastomeric (meth)acrylate oligomers are mixed with one or more diluent comonomers, one or more radiopaque fillers and one or more polymerization initiator systems. One or more antimicrobial agents may also be included in the composition. The components are mixed, undergo a setting reaction and are subsequently cured. In use, the composition is easily removed from the tooth structure if rework is needed, yet provides a tight and effective seal in the root canal. The composition also has a desirable flowable consistency and exhibits good adhesiveness with a tooth substrate.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Brief introduction of 3-Chloro-6-fluorobenzo[d]isoxazole

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5- And/or 7-substituted pyrazolo-[4,3-b]-pyridines and their use as antiinflammatory agents

Compounds of the formula (I) and pharmaceutically acceptable salts thereof: STR1 wherein: the first of R1 and R2 is hydrogen, C1-4 alkyl or phenyl optionally substituted by one or two substituents selected from halogen, CF3, C1-4 alkoxy or alkyl and the second is SR4 wherein R4 is phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl, or NR5 R6 wherein R5 and R6 are independently selected from hydrogen, C1-6 alkyl, C3-8 cycloalkyl, phenyl or phenyl C1-4 alkyl either of which phenyl moieties may be substituted by one or two substituents selected from halogen, CF3, C1-4 alkoxy or C1-4 alkyl, or R5 and R6 together form C4-6 polymethylene; and R3 is hydrogen, C1-4 alkyl or benzyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory activity, a process for their preparation and their use as pharmaceuticals.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Final Thoughts on Chemistry for 65685-51-0

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Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles

The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product’s physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid?base work-up. As expected, a range of functional groups was compatible with the chemistry.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

More research is needed about 3-Chloro-6-fluorobenzo[d]isoxazole

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Certain anti-inflammatory pyrazolo [4,3-b] pyridine 7-amines

A compound of the formula (1) or a salt or solvate thereof: STR1 in which: R0 is hydrogen or C1-6 alkyl; R1 and R2 are both hydrogen; or R1 is hydrogen, C1-6 alkyl; and R2 is CN; CR5 R6 Y where R5 and R6 are independently selected from hydrogen and C1-4 alkyl and Y is selected from hydrogen, OR7 or SR7 where R7 is hydrogen, C1-4 alkyl or C2-4 alkanoyl, and NR8 R9 where R8 and R9 are independently hydrogen, C1-4 alkyl, C2-4 alkenyl or C2-4 alkanoyl or together are C4-6 polymethylene; or COR10 is OH or C1-4 alkyl, or COR10 is a pharmaceutically acceptable ester or amide; or R2 is hydrogen, C1-6 alkyl, or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; and R1 is CN, CR5 R6 Y or COR10 as defined for R2 above; or R1 and R2 together form C3 -C6 polymethylene optionally substituted by C1 -C4 alkyl; R3 is –(CH2)n CO2 R11, –(CH2)n CONR12 R13,–(CH2)n CN, –(CH2)m NHCOR14, STR2 where a, b, n, m and p are integers and n is 1 to 10, m is 2 to 10, p is 3 to 5, a is 1 to 3, and b is 1 to 3, and R11 is hydrogen, C1-8 alkyl, benzyl or phenyl, R12 and R13 are independently hydrogen, C1-6 alkyl, benzyl or phenyl, or together form C3-8 alkylene, R14 is C1-4 alkyl, benzyl or phenyl and X is oxygen, sulphur, NH or N–C1-4 alkyl, and R4 is hydrogen; or C1-4 alkyl or benzyl optionally substituted in the phenyl ring by one or two of halogen, CF3, C1-4 alkoxy or C1-4 alkyl, and is attached at nitrogen atom 1 or 2, a process for its preparation and its use as a pharmaceutical.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics