Day: March 19, 2021

52356-01-1, Name is 2-Hydrazinobenzoic acid hydrochloride, molecular formula is C7H9ClN2O2, Product Details of 52356-01-1, belongs to Benzisoxazole compound, is a common compound. In a patnet, author is Deng, BL, once mentioned the new application about 52356-01-1.

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

The HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) constitute a large and structurally diverse set of compounds, several of which are currently used in the treatment of AIDS. A series of novel alkenyldiarylmethanes (ADAMs) were designed and synthesized as part of an ongoing investigation to replace the metabolically labile methyl ester moieties found in the ADAM pharmacophore with stable modifications that retain the potent anti-HIV activity of the parent compounds. Unsurprisingly, the rat plasma half-lives of the new ADAMs were not improved when compared to the parent compounds, but all of the synthesized ADAMs inhibited the cytopathic effect of HIV-1 in cell culture. The most potent compound identified was (E)-5-[1-(3,7-dimethyl-2oxo-2,3-dihydro-benzoxazol-5-yl)-5-methoxycarbonyl-pent-1-enyl]-2-methoxy-3-methylbenzoic acid methyl ester (7), which inhibited the cytopathic effects of both HIV-1(RF) and HIV-1(IIIB) strains in cell cultures with EC50 values of 30 and 90 nM, respectively, and inhibited HIV-1 reverse transcriptase with an IC50 of 20 nM. (c) 2005 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 52356-01-1 help many people in the next few years. Product Details of 52356-01-1.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 127-17-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 127-17-3, Name is 2-Oxopropanoic acid, SMILES is CC(C(O)=O)=O, belongs to Benzisoxazole compound. In a article, author is NAKASA, H, introduce new discover of the category.

RAT-LIVER MICROSOMAL CYTOCHROME-P-450 RESPONSIBLE FOR REDUCTIVE METABOLISM OF ZONISAMIDE

The reductive metabolism of 1,2-benzisoxazole-3-methanesulfonamide (zonisamide) to 2-sulfamoylacetylphenol (SMAP) was observed in liver microsomes from female rats, as well as male rats, but the SMAP-producing activity in female rats was 4-fold lower than that found in male rats. In addition, the reductive metabolism of zonisamide in liver microsomes was induced by the treatment of male rats with phenobarbital. However, the SMAP-producing activity did not correlate positively with the amounts of P-450 2B1 and P-450 2C11 immunochemically determined. In contrast, the reductive metabolism of zonisamide was also found to be induced by the pretreatment of male rats with pregnenolone 16alpha-carbonitrile, triacetyloleandomycin, and dexamethasone. Furthermore, the SMAP-producing activity correlated highly with the amount of P-450 cross-reactive with antihuman P-450 3A4 antibody, suggesting that P-450 3A1/2 may function in the reductive metabolism of zonisamide. In addition, the P-450 PCNa (3A2) exhibited the SMAP-producing activity in a reconstituted system. The antihuman P-450 3A4 antibody inhibited markedly the formation of SMAP from zonisamide in male rat liver microsomes. These results indicate that cytochrome(s) P-450 belonging to P-450 3A subfamily may be predominantly responsible for the reductive metabolism of zonisamide in rat liver microsomes.

Synthetic Route of 127-17-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 127-17-3 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Application of 15026-17-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 15026-17-2, Name is 4-(tert-Butoxy)-4-oxobutanoic acid, SMILES is CC(C)(C)OC(=O)CCC(O)=O, belongs to Benzisoxazole compound. In a article, author is Chauhan, Jay, introduce new discover of the category.

One-pot synthesis of 2,1-benzisoxazoles (anthranils) by a stannous chloride-mediated tandem reduction-heterocyclization of 2-nitroacylbenzenes under neutral conditions

Classically, 2,1-benzisoxazoles (anthranils) are prepared from 2-nitroacylbenzenes by a reductive heterocyclization reaction with Sn or SnCl2 concentrated HCl. Acid sensitive functionalities are expected to be incompatible with these conditions; milder approaches to the synthesis of 2,1-benzisoxazoles would be welcomed. We demonstrate that SnCl2 center dot 2H(2)O in a 1:1 mixture of EtOAc/MeOH is capable of mediating the tandem reduction-heterocyclization of a variety of 2-nitroacylbenzenes to their corresponding 2,1-benzisoxazoles in good to excellent yields under essentially neutral conditions. Importantly, several commonly used acid-labile protecting groups, including Boc carbamate, tert-butyl ether, and tert-butyl ester, proved orthogonal to these reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

Application of 15026-17-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 15026-17-2.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 52356-01-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 52356-01-1, Name is 2-Hydrazinobenzoic acid hydrochloride, SMILES is O=C(O)C1=CC=CC=C1NN.[H]Cl, belongs to Benzisoxazole compound. In a article, author is Kikuchi, Kazuya, introduce new discover of the category.

Toward bifunctional antibody catalysis

Antibodies that catalyze the deprotonation of unactivated benzisoxazoles to give the corresponding salicylonitriles were prepared using as antigen a 2-aminobenzimidazolium derivative coupled to a carrier protein via its benzene ring. The hapten was designed to induce an antibody binding site with both a base and an acid, in position to initiate proton transfer and stabilize developing negative charge at the phenoxide leaving group, respectively. Consistent with this design, the catalysts exhibit bell-shaped pH-rate profiles, while chemical modification identified several functional groups that could participate in bifunctional catalysis. One of the antibodies, 13G5, is particularly notable in catalyzing the elimination of 6-glutaramidebenzisoxazole with a > 10(5)-fold rate acceleration over background and an effective molarity of > 10(4) M for its catalytic base. These properties compare favorably to the efficiencies achieved by the best previously characterized antibodies with substantially more reactive substrates. (c) 2006 Elsevier Ltd. All rights reserved.

Electric Literature of 52356-01-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 52356-01-1.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 505-48-6, Name is Octanedioic acid, molecular formula is C8H14O4, belongs to Benzisoxazole compound, is a common compound. In a patnet, author is Shelke, Amol V., once mentioned the new application about 505-48-6, Safety of Octanedioic acid.

Oxidation of 1-Amidoalkyl-2-naphthols Using (Diacetoxyiodo)benzene: Unusual Formation of 1-Arylnaphtho[1,2-d]isoxazoles

The reactions of 1-amidoalkyl-2-naphthols with (diacetoxyiodo)benzene results in the unusual formation of 1-arylnaphtho[1,2-d]isoxazoles. This procedure demonstrates a useful application of (diacetoxyiodo) benzene for the oxidative formation of an N-O bond.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 505-48-6. The above is the message from the blog manager. Safety of Octanedioic acid.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 5117-19-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 5117-19-1, Name is 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, SMILES is OCCOCCOCCOCCOCCOCCOCCOCCO, belongs to Benzisoxazole compound. In a article, author is HAYAKAWA, T, introduce new discover of the category.

ZONISAMIDE REDUCES HYPOXIC-ISCHEMIC BRAIN-DAMAGE IN NEONATAL RATS IRRESPECTIVE OF ITS ANTICONVULSIVE EFFECT

The neuroprotective effect of a novel anticonvulsant, zonisamide, was investigated in neonatal rats with hypoxic-ischemic brain damage. Rats underwent left carotid ligation followed by hypoxic exposure (8% 0(2)) for 2.5 h. When zonisamide (75 mg/kg) was administered i.p. 1 h before hypoxia, it reduced the cortical infarction volume to 6 +/- 5% (mean +/- S.E.M.) from 68 +/- 7% in vehicle-treated controls and the striatal volume to 8 +/- 4% from 78 +/- 7%. Zonisamide also reduced neuronal necrosis in 5 hippocampal regions (the dentate gyrus, CA4, CA3, CA1, and the subiculum). The plasma zonisamide concentration before and after hypoxia was 47.9 +/- 2.0 mu g/ml and 42.3 +/- 3.9 mu g/ml, respectively. Epidural electrodes were implanted in 6 pups one day before hypoxia-ischemia. Electroencephalograms were recorded during hypoxia-ischemia in rats given zonisamide or vehicle before the insult. The intensity of seizure activities was similar in the zonisamide-treated pups and the vehicle-treated controls. These findings demonstrate that zonisamide reduces neonatal hypoxic-ischemic brain damage and that this protective effect does not depend on its anticonvulsant action.

Synthetic Route of 5117-19-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 5117-19-1 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of 90-27-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 90-27-7, Name is 2-Phenylbutanoic acid, SMILES is CCC(C1=CC=CC=C1)C(O)=O, belongs to Benzisoxazole compound. In a article, author is MAKOSZA, M, introduce new discover of the category.

DOES NITROARYLATION OF PHENYLACETONITRILE PROCEED AS A PHASE-TRANSFER-CATALYZED PROCESS

The phase-transfer catalyzed reaction of phenylacetonitrile with 4-chloro-3-(trifluoromethyl)nitrobenzene produces 5-chloro-7-phenyl-4-(trifluoromethyl)benzisoxazole (5) not the nitroarylation product 3a as was reported by Durantini et al. (Durantini, E. N.; Chiacchiera, S. M.; Silber, J. J. J. Org. Chem. 1993, 58, 7115). The catalytic nitroarylation does not occur because the product 3a immediately forms a lipophilic carbanion which inhibits the catalytic process. The nitroarylation occurs under ion-pair extraction conditions when a stoichiometric amount of tetrabutylammonium bromide is used, whereas 2-phenylalkanenitriles are efficiently PTC nitroarylated. 4-Chloro-3-(trifluoromethyl)- and 2-chloro-5-(trifluoromethyl)nitrobenzenes enter vicarious nucleophilic substitution reactions with carbanions of chloromethyl p-tolyl sulfone. These results and formation of 5 show that carbanions add to these nitroarenes initially in positions occupied with hydrogen.

Synthetic Route of 90-27-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 90-27-7 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 629-25-4, Name is Sodium Laurate, SMILES is CCCCCCCCCCCC([O-])=O.[Na+], belongs to Benzisoxazole compound. In a document, author is Mikhailovskii, A. G., introduce the new discover, Quality Control of Sodium Laurate.

2-AROYLHEXANONES IN THE SYNTHESIS OF AZOLES

2-Aroylcyclohexanones, obtained from piperidinocyclohexene, react with hydrazine, hydroxylamine, and o-phenylenediamine to give the corresponding derivatives of bicyclic heterocycles – indazole, 2,1-benzisoxazole, and 2-spiro-cyclohexylbenzimidazole. The structure of a derivative of benzyloxazole has been determined by X-ray crystallography.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 629-25-4 is helpful to your research. Quality Control of Sodium Laurate.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C7H12O4, 40052-13-9, Name is 3-Tert-butoxy-3-oxopropanoic acid, SMILES is CC(C)(C)OC(=O)CC(O)=O, in an article , author is Ricci, A, once mentioned of 40052-13-9.

Methoxylation modifies the activity of 1,2-benzisoxazole-3-acetic acid: 6,7-dimethoxy-1,2-benzisoxazole-3-acetic acid is an auxin antagonist in cytokinin mediated processes

The insertion of a methoxy group in different positions of the aromatic ring modifies the activity of 1,2-benzisoxazole-3-acetic acid (BOAA), a specific morphogenetic compound with no activity on cell elongation or root growth. Monomethoxylation in the 4- and 7-position is critical in determining the kind of activity: 4-OMeBOAA induces stem elongation, inhibits root growth and does not improve shoot production; 7-OMeBOAA inhibits stem elongation and shoot production and is unable to induce root growth. 6,7-OMeBOAA, inactive on stem elongation and root growth, is unable to induce the expression of Pg5-GUS gene in the presence of BAP and inhibits the expression of this gene when induced by BAP plus IAA. Furthermore, 6,7-OMeBOAA inhibits completely shoot production and can therefore be regarded as an auxin antagonist in these cytokinin-mediated processes.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 40052-13-9, you can contact me at any time and look forward to more communication. COA of Formula: C7H12O4.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 40052-13-9, Name is 3-Tert-butoxy-3-oxopropanoic acid, molecular formula is , belongs to Benzisoxazole compound. In a document, author is Reddy, C. B. Rajashekar, Category: Benzisoxazole.

HDAC and NF-kappa B mediated cytotoxicity induced by novel N-Chloro beta-lactams and benzisoxazole derivatives

Novel N-chloro a-Lactam and benzisoxazole derivatives were successfully synthesized with excellent yields (92-96%) under simple and mild reaction conditions. The beta-lactams as a class acquired importance since the discovery of penicillin which contains beta-lactam unit as an essential structural feature of its molecule, this interest continued unabated because of the therapeutic importance of beta-lactam antibiotics. In silico studies of the compounds with cancer drug target enzymes showed the inhibition of HDAC (Histone Deacetylase) and NF-kappa B (nuclear factor kappa-light-chain-enhancer of activated B cells) significantly. The compounds were then investigated for the inhibitory potential against the same enzymes in vitro. NF-kappa B inhibition was investigated by trans activation assay using HEK293/NF-kappa B-luc cells. Overall, the synthesized compounds induce the cancer cell toxicity by restraining the NF-kappa B transcription factor mediated by HDAC inhibition and thus the compounds act as dual inhibitors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 40052-13-9, in my other articles. Category: Benzisoxazole.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics