Day: November 2, 2021

HPLC of Formula: C10H12O2. Mandrelli, F; Blond, A; James, T; Kim, H; List, B in [Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany published Deracemizing alpha-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol in 2019, Cited 52. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7.

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers alpha-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of alpha-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asymmetric protonation.

Welcome to talk about 90-27-7, If you have any questions, you can contact Mandrelli, F; Blond, A; James, T; Kim, H; List, B or send Email.. HPLC of Formula: C10H12O2

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 90-27-7. In 2020 ORGANOMETALLICS published article about DENSITY-FUNCTIONAL THEORY; CO2 INSERTION; CARBON; ALKENES; DFT; HYDROCARBOXYLATION; THERMOCHEMISTRY in [Obst, Marc F.; Hopmann, Kathrin H.] UiT Arctic Univ Norway, Hylleraas Ctr Quantum Mol Sci, Dept Chem, N-9037 Tromso, Norway; [Gevorgyan, Ashot; Bayer, Annette] UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway in 2020, Cited 38. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7.

The copper-NHC-catalyzed carboxylation of organo-boranes with CO2 was investigated using computational and experimental methods. The DFT and DLPNO-CCSD(T) results indicate that nonbenzylic substrates are converted via an inner-sphere carboxylation of an organocopper intermediate, whereas benzylic substrates may simultaneously proceed along both inner- and outer-sphere CO2 insertion pathways. Interestingly, the computations predict that two conceptually different carboxylation mechanisms are possible for benzylic organoboranes, one being copper-catalyzed and one being mediated by the reaction additive CsF. Our experimental evaluation of the computed reactions confirms that carboxylation of nonbenzylic substrates requires copper catalysis, whereas benzylic substrates can be carboxylated with and without copper.

Welcome to talk about 90-27-7, If you have any questions, you can contact Obst, MF; Gevorgyan, A; Bayer, A; Hopmann, KH or send Email.. SDS of cas: 90-27-7

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Recently I am researching about B(C6F5)(3)-CATALYZED HYDROSILYLATION; CARBONYL; MECHANISM; SILANES, Saw an article supported by the Berlin Graduate School of Natural Sciences and Engineering; Projekt DEAL. Name: 2-Phenylbutanoic acid. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Roy, A; Oestreich, M. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid

Little-explored hydrosilylation of ketenes promoted by main-group catalysts is reported. The boron Lewis acid tris(pentafluorophenyl)borane accelerates the slow uncatalyzed reaction of ketenes and hydrosilanes, thereby providing a convenient access to the new class of beta,beta-di- and beta-monoaryl-substituted aldehyde-derived silyl enol ethers. Yields are moderate to high, and Z configuration is preferred. The corresponding silyl bis-enol ethers are also available when using dihydrosilanes. The related trityl-cation-initiated hydrosilylation involving self-regeneration of silylium ions is far less effective.

Welcome to talk about 90-27-7, If you have any questions, you can contact Roy, A; Oestreich, M or send Email.. Name: 2-Phenylbutanoic acid

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In 2019 SCI TOTAL ENVIRON published article about OXIDATIVE STRESS; OXIDE NANOPARTICLES; TRYPTOPHAN-METABOLISM; SILVER NANOPARTICLES; DIFFERENT SIZES; CYTOTOXICITY; METABOLOMICS; INFLAMMATION; EXPRESSION; NANOMATERIALS in [Dong, Li; Tang, Song; Deng, Fuchang; Zhao, Kangfeng; Fang, Jianlong; Bai, Xuetao; Zhang, Hongwei] Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, Beijing 100021, Peoples R China; [Tang, Song] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Nanjing 211166, Jiangsu, Peoples R China; [Deng, Fuchang] Southwest Univ, Coll Biotechnol, Chongqing 400715, Peoples R China; [Gong, Yufeng; Hecker, Markus; Giesy, John P.] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada; [Zhou, Jianjun] Tongji Univ, Sch Med, East Hosp, Res Ctr Translat Med,Canc Stem Cell Inst, Shanghai 310000, Peoples R China; [Liang, Donghai] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA; [Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada; [Giesy, John P.] Univ Saskatchewan, Dept Biomed & Vet Biosci, Saskatoon, SK S7N 5B4, Canada; [Giesy, John P.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA in 2019, Cited 64. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Product Details of 90-27-7

Nanosized alumina (Al2O3-NPs), a widely used nanoparticle in numerous commercial applications, is released into environment posing a threat to the health of wildlife and humans. Recent research has revealed essential roles of physicochemical properties of nanoparticles in determining their toxicity potencies. However, influence of shape on neurotoxicity induced by heterogeneous Al2O3 -NPs remains unknown. We herein compared the neurotoxicity of two shapes of gamma-Al2O3-NPs (flake versus rod) and their effects on metabolic profiles of astrocytes in rat cerebral cortex. While exposed to both shapes caused significant cytotoxicity and apoptosis in a dose-dependent manner after 72 h exposure, a significantly stronger response was observed for nanorods than for nanoflakes. These effects were associated with significantly greater ROS accumulation and inflammation induction, as indicated by increased concentrations of IL-1 beta, IL-2 and IL-6. Using untargeted metabolomics, significant alternations in metabolism of amino adds, lipids and purines, and pyrimidines were observed after exposure to both types. Moreover, changes in the metabolome caused by nanorods were significantly greater than those by nanoflakes as also indicated by physiological stress responses to ROS, inflammation, and apoptosis. Taken together, these findings demonstrated the critical role of morphology in determining toxic potencies of nanoalumina and its underlying mechanisms of toxic actions. (C) 2019 Elsevier B.V. All rights reserved.

Welcome to talk about 90-27-7, If you have any questions, you can contact Dong, L; Tang, S; Deng, FC; Gong, YF; Zhao, KF; Zhou, JJ; Liang, DH; Fang, JL; Hecker, M; Giesy, JP; Bai, XT; Zhang, HW or send Email.. Product Details of 90-27-7

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Reactivity Tuning for Radical-Radical Cross-Coupling via Selective Photocatalytic Energy Transfer: Access to Amine Building Blocks published in 2019. SDS of cas: 90-27-7, Reprint Addresses Cho, EJ (corresponding author), Chung Ang Univ, Dept Chem, 84 Heukseok Ro, Seoul 06974, South Korea.; You, Y (corresponding author), Ewha Womans Univ, Div Chem Engn & Mat Sci, Seoul 03760, South Korea.. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid

Reductive N-O bond cleavage has been widely explored for providing either N or O radical species for various coupling processes. Despite significant advances, this photoredox pathway is less appealing due to poor atom economy owing to the loss of one fragment during the transformation. In this regard, the homolytic N-O bond cleavage by an energy-transfer pathway to provide two key radicals would be highly desirable for overcoming the limitations of the use of one fragment. We report an exclusive energy-transfer approach for the development of a challenging radical-radical C(sp(3))-N cross-coupling process by reactivity-tuning of the catalytic system. The homolytic N-O bond cleavage of oxime esters in the presence of an Ir complex produces acyloxy and iminyl radicals, which undergo decarboxylative cross-coupling to yield valuable imines (typically 0.25 mol % cat. and 1 h reaction time). Extensive photophysical and electrochemical measurements, as well as density functional theory studies, were carried out to probe the mechanism and the operation of a Dexter-type energy-transfer pathway was revealed. The choice of solvent (EtOAc) and reaction concentration were critical for achieving the selectivity and reactivity in this cross-coupling process. The synthetic utility of this method was explored by studying highly functionalized oxime esters, including derivatives of biologically active natural products and drug molecules. Furthermore, in situ transformations of the imine products into pharmaceutically important amines were also demonstrated, showcasing the utility of the imine products as valuable amine building blocks.

Welcome to talk about 90-27-7, If you have any questions, you can contact Soni, VK; Lee, S; Kang, J; Moon, YK; Hwang, HS; You, Y; Cho, EJ or send Email.. SDS of cas: 90-27-7

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

An article Reactivity Tuning for Radical-Radical Cross-Coupling via Selective Photocatalytic Energy Transfer: Access to Amine Building Blocks WOS:000494549700072 published article about REDOX-ACTIVE ESTERS; PHOTOCHEMICAL GENERATION; O-ACYLOXIMES; PHOTOREDOX; CATALYSIS; N-(ACYLOXY)PHTHALIMIDES; SECONDARY; AMINATION; MECHANISM; OXIMES in [Soni, Vineet Kumar; Kang, Jihee; Hwang, Ho Seong; Cho, Eun Jin] Chung Ang Univ, Dept Chem, 84 Heukseok Ro, Seoul 06974, South Korea; [Lee, Sumin; Moon, Yu Kyung; You, Youngmin] Ewha Womans Univ, Div Chem Engn & Mat Sci, Seoul 03760, South Korea in 2019, Cited 82. Computed Properties of C10H12O2. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7

Reductive N-O bond cleavage has been widely explored for providing either N or O radical species for various coupling processes. Despite significant advances, this photoredox pathway is less appealing due to poor atom economy owing to the loss of one fragment during the transformation. In this regard, the homolytic N-O bond cleavage by an energy-transfer pathway to provide two key radicals would be highly desirable for overcoming the limitations of the use of one fragment. We report an exclusive energy-transfer approach for the development of a challenging radical-radical C(sp(3))-N cross-coupling process by reactivity-tuning of the catalytic system. The homolytic N-O bond cleavage of oxime esters in the presence of an Ir complex produces acyloxy and iminyl radicals, which undergo decarboxylative cross-coupling to yield valuable imines (typically 0.25 mol % cat. and 1 h reaction time). Extensive photophysical and electrochemical measurements, as well as density functional theory studies, were carried out to probe the mechanism and the operation of a Dexter-type energy-transfer pathway was revealed. The choice of solvent (EtOAc) and reaction concentration were critical for achieving the selectivity and reactivity in this cross-coupling process. The synthetic utility of this method was explored by studying highly functionalized oxime esters, including derivatives of biologically active natural products and drug molecules. Furthermore, in situ transformations of the imine products into pharmaceutically important amines were also demonstrated, showcasing the utility of the imine products as valuable amine building blocks.

Welcome to talk about 90-27-7, If you have any questions, you can contact Soni, VK; Lee, S; Kang, J; Moon, YK; Hwang, HS; You, Y; Cho, EJ or send Email.. Computed Properties of C10H12O2

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

An article Homo-and heteroleptic Zinc(II) carboxylates: Synthesis, structural characterization, and assessment of their biological significance in in vitro models WOS:000553340500003 published article about TRANSITION-METAL-COMPLEXES; ALKALINE-PHOSPHATASE; CRYSTAL-STRUCTURES; DNA-BINDING; SPECTROSCOPIC CHARACTERIZATION; INDOLE-2-CARBOXYLIC ACID; ENZYME-INHIBITION; ZN(II); LIGAND; DRUG in [Naz, Saba; Uddin, Noor; Ullah, Kaleem; Haider, Ali; Ali, Saqib] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Gul, Amna; Faisal, Sulaiman; Nadhman, Akhtar] CECOS Univ, Dept Biotechnol, Inst Integrat Biosci, Peshawar, Pakistan; [Bibi, Memoona; Yousuf, Sammer] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan in 2020, Cited 77. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Computed Properties of C10H12O2

A series of five new zinc(II) complexes of 2-phenylbutyric acid comprising of one homoleptic (1) and four heteroleptic (2-5) complexes were synthesized under open beaker conditions. The behavior of the complexes in the solid and solution state was explored through FT-IR and NMR (H-1 and C-13) spectroscopy, respectively. Crystallographic data have revealed that complexes 2 and 3 crystallized in monoclinic and triclinic crystal system, respectively, with a distorted octahedral geometry, whereas complex 4 crystallized in monoclinic crystal system with a pentagonal geometry around the zinc(II) atom. All the complexes have been screened for enzyme (alkaline phosphatase) inhibition, in vitro hemolysis and antileishmanial activity, DNA and cetyl-trimethylammonium bromide (CTAB) interaction. The increase in the concentration of complexes 1, 2, 4 and 5 remarkably decreases the activity of enzyme alkaline phosphatase, whereas complex 3 was found inactive. The behavior of the complexes as a potent drug is clear from the results of hemolysis and antileishmanial activity against promastigote. The UV-Vis spectroscopic data of complexes-DNA interactions suggested a surface binding mode whereas the interaction of CTAB with complexes, studied through conductometry, confirmed strong in-teracting ability of complexes with CTAB.

Welcome to talk about 90-27-7, If you have any questions, you can contact Naz, S; Uddin, N; Ullah, K; Haider, A; Gul, A; Faisal, S; Nadhman, A; Bibi, M; Yousuf, S; Ali, S or send Email.. Computed Properties of C10H12O2

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Ye, ZH; Wu, YQ; Chen, N; Zhang, H; Zhu, K; Ding, MR; Liu, M; Li, Y; Zhang, FZ in [Ye, Zenghui; Chen, Na; Zhang, Hong; Zhu, Kai; Ding, Mingruo; Liu, Min; Li, Yong; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China; [Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China published Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives in 2020, Cited 48. Safety of 2-Phenylbutanoic acid. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7.

Triazolopyridinone derivatives are of high value in both medicinal and material chemistry. However, the chiral or hindered triazolopyridinone derivatives remain an underexplored area of chemical space because they are difficult to prepare via conventional methods. Here we report an electrochemical rearrangement for the efficient synthesis of otherwise inaccessible triazolopyridinones with diverse alkyl carboxylic acids as starting materials. This enables the efficient preparation of more than 60 functionalized triazolopyridinones under mild conditions in a sustainable manner. This method is evaluated for the late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it is further applied to the decagram scale preparation of enantiopure triazolopyridinones. The control experiments support a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrates the power of electrochemical synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chemistry. Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.

Welcome to talk about 90-27-7, If you have any questions, you can contact Ye, ZH; Wu, YQ; Chen, N; Zhang, H; Zhu, K; Ding, MR; Liu, M; Li, Y; Zhang, FZ or send Email.. Safety of 2-Phenylbutanoic acid

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In 2020 CHINESE CHEM LETT published article about CARBOXYLIC-ACIDS; PHENYLACETIC ACIDS; AEROBIC OXIDATION; CATALYST; PHOSPHORYLATION; ARYLHYDRAZINES; BENZYLATION; PALLADIUM; ACYLATION; ALCOHOLS in [He, Shuaiqi; Chen, Xiaolan; Zeng, Fanlin; Lu, Peipei; Qu, Lingbo; Yu, Bing] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China; [Yu, Bing] Henan Nonferrous Met Geol Explorat Inst, Zhengzhou 450052, Peoples R China; [Peng, Yuyu] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China in 2020, Cited 66. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Name: 2-Phenylbutanoic acid

A metal-free photocatalytic oxidative decarboxylation reaction at room temperature was developed for the synthesis of aromatic aldehydes and ketones from the corresponding arylacetic acids. The reaction was realized under blue-light irradiation by adding 1 mol% of 4CzIPN as photocatalyst and air as oxidant. This reaction represents a novel decarboxylation of a sp(3) -hybridized carboxylic acids without traditional heating, additional oxidants, and metal reagents under mild conditions. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Welcome to talk about 90-27-7, If you have any questions, you can contact He, SQ; Chen, XL; Zeng, FL; Lu, PP; Peng, YY; Qu, LB; Yu, B or send Email.. Name: 2-Phenylbutanoic acid

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Recently I am researching about REDOX-ACTIVE ESTERS; DESIGN; STRATEGY; ACIDS, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21871234]; Zhejiang Provincial NSFC for Distinguished Young Scholars [LR15H300001]. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Ye, ZH; Wu, YQ; Chen, N; Zhang, H; Zhu, K; Ding, MR; Liu, M; Li, Y; Zhang, FZ. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid. Product Details of 90-27-7

Triazolopyridinone derivatives are of high value in both medicinal and material chemistry. However, the chiral or hindered triazolopyridinone derivatives remain an underexplored area of chemical space because they are difficult to prepare via conventional methods. Here we report an electrochemical rearrangement for the efficient synthesis of otherwise inaccessible triazolopyridinones with diverse alkyl carboxylic acids as starting materials. This enables the efficient preparation of more than 60 functionalized triazolopyridinones under mild conditions in a sustainable manner. This method is evaluated for the late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it is further applied to the decagram scale preparation of enantiopure triazolopyridinones. The control experiments support a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrates the power of electrochemical synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chemistry. Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.

Welcome to talk about 90-27-7, If you have any questions, you can contact Ye, ZH; Wu, YQ; Chen, N; Zhang, H; Zhu, K; Ding, MR; Liu, M; Li, Y; Zhang, FZ or send Email.. Product Details of 90-27-7

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics