Day: March 30, 2022

Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Crown Ethers and Their Alkali Metal Ion Complexes as Assembler Groups in Uranyl-Organic Coordination Polymers with cis-1,3-, cis-1,2-, and trans-1,2-Cyclohexanedicarboxylates. Author is Thuery, Pierre; Atoini, Youssef; Harrowfield, Jack.

Alkali metal cations (Na+, K+) and crown ether mols. (12C4, 15C5, 18C6) were used as addnl. reactants during the hydrothermal synthesis of uranyl ion complexes with cis/trans-1,3-, cis-1,2- and trans-1,2-cyclohexanedicarboxylic acids (c/t-1,3-chdcH2, c-1,2-chdcH2, and t-1,2-chdcH2, resp., the latter as racemic or pure (1R,2R) enantiomer). Oxalate anions generated in situ are present in all the six complexes isolated and crystallog. characterized, [(UO2)2(c-1,3-chdc)2(C2O4)][UO2(H2O)5]·(12C4)·2H2O (1), [(UO2)4Na2(c-1,2-chdc)2(C2O4)3(15C5)2] (2), [(UO2)4K2(c-1,2-chdc)2(C2O4)3(18C6)1.5(H2O)1.5] (3), [(UO2)12K5(R-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (4), [(UO2)12K5(rac-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (5), and [(UO2)8K4(rac-t-1,2-chdc)4(C2O4)6(18C6)3(H2O)2] (6). In complex 1, the [UO2(H2O)5]2+ counterions link the ladderlike uranyl-containing one-dimensional polymers and the uncomplexed crown ether mols. through hydrogen bonds. In all the other complexes, two-dimensional uranyl/chdc/oxalate subunits are formed, with topologies depending on the stoichiometry, in which the 1,2-chdc2- ligands are bound to three uranium atoms, one of them chelated by the two carboxylate groups, and the oxalate ligands are bis-chelating. In complex 2, the Na(15C5)+ cations are bound to one layer through double Na-carboxylate or Na-oxo cis-bonding and they are thus mere decorating groups. In contrast, the quasi-planar K(18C6)+ groups in 3-6, partially affected by disorder, are generally trans-coordinated to two uranyl oxo groups pertaining to different layers, thus uniting the latter into a three-dimensional framework.

There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1[C@@H](C(O)=O)CCCC1)O)Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid, and with the development of science, more effects of this compound(610-09-3) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 610-09-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Fractal to monolayer growth of AgCl and Ag/AgCl nanoparticles on vanadium oxides (VOx) for visible-light photocatalysis. Author is Sharma, Mukesh; Das, Biraj; Sarmah, Jugal Charan; Hazarika, Anil; Deka, Biplab K.; Park, Young-Bin; Bania, Kusum K..

A facile and simple methodol. was adopted for the trapping of highly crystalline AgCl and Ag/AgCl nanoparticles (NPs) into the interlayer spacings of vanadium oxides (VOx). Self-organization of AgCl and Ag/AgCl-NPs on VOx was found to be governed by the nature of the dicarboxylic acids used during the synthesis of the nanocomposites. A “”fractals-like”” morphol. of the AgCl@VOx nanocomposite was achieved in the presence of cis-1,2 cyclohexanedicarboxylic acid. Heating of the AgCl@VOx nanocomposite above 68 °C resulted in the growth of polydispersed and ultrafine (3-4 nm) Ag/AgCl-NPs and its self-organization into monolayer formation on a partly crystalline VOx matrix. Change in the conformation of the dicarboxylic acid to the trans-isomer resulted in the formation of a ‘rod-like’ structure of Ag/AgCl-NPs on a highly crystalline VOx matrix. The band gaps of the nanocomposites were within the range of 1.8 to 2.9 eV. Because of such a low band gap, the synthesized nanocomposites were found to be highly active toward the photooxidation of methylene (MB) and methyl orange (MO) under sunlight.

There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1[C@@H](C(O)=O)CCCC1)O)SDS of cas: 610-09-3, and with the development of science, more effects of this compound(610-09-3) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inorganic Chemistry called Water-Soluble Dioxidovanadium(V) Complexes of Aroylhydrazones: DNA/BSA Interactions, Hydrophobicity, and Cell-Selective Anticancer Potential, Author is Sahu, Gurunath; Banerjee, Atanu; Samanta, Rajib; Mohanty, Monalisa; Lima, Sudhir; Tiekink, Edward R. T.; Dinda, Rupam, which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Application In Synthesis of 2-Furoic hydrazide.

Five new anionic aqueous dioxidovanadium(V) complexes, [{VO2L1,2}A(H2O)n]α (1-5), with the aroylhydrazone ligands pyridine-4-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L1) and furan-2-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L2) incorporating different alkali metals (A = Na+, K+, Cs+) as countercation were synthesized and characterized by various physicochem. techniques. The solution-phase stabilities of 1-5 were determined by time-dependent NMR and UV-visible, and also the octanol/water partition coefficients were obtained by spectroscopic techniques. X-ray crystallog. of 2-4 confirmed the presence of vanadium(V) centers coordinated by two cis-oxido-O atoms and the O, N, and O atoms of a dianionic tridentate ligand. To evaluate the biol. behavior, all complexes were screened for their DNA/protein binding propensity through spectroscopic experiments Finally, a cytotoxicity study of 1-5 was performed against colon (HT-29), breast (MCF-7), and cervical (HeLa) cancer cell lines and a noncancerous NIH-3T3 cell line. The cytotoxicity was cell-selective, being more active against HT-29 than against other cells. In addition, the role of hydrophobicity in the cytotoxicity was explained in that an optimal hydrophobicity is essential for high cytotoxicity. Moreover, the results of wound-healing assays indicated antimigration in case of HT-29 cells. Remarkably, 1 with an IC50 value of 5.42 ± 0.15μM showed greater activity in comparison to cisplatin against the HT-29 cell line.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Application In Synthesis of 2-Furoic hydrazide, and with the development of science, more effects of this compound(3326-71-4) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium-catalyzed Suzuki coupling synthesis and biological activities of ten new 1,3,4-oxadiazole derivatives, published in 2020-03-31, which mentions a compound: 3326-71-4, mainly applied to chloroquinolinylthio aryloxadiazole preparation phenylboronic acid Suzuki Coupling; phenylquinolinylthio aryloxadiazole preparation antibacterial antifungal, Reference of 2-Furoic hydrazide.

Ten new 2-phenyl-5-((7-phenylquinolin-4-yl)thio)-1,3,4-oxadiazole derivatives I [R = Ph, 3-pyridyl, 4-methoxyphenyl, etc.] were synthesized and their biol. activities were reported. Dichloroquinoline on sequential reactions with different moieties such as 1,3,4-oxadiazole and phenylboronic acid gave desired target derivatives I with excellent yield. In-vitro antimicrobial activity of the synthesized compounds I was evaluated against Gram-pos. and Gram-neg. bacteria. The synthetic steps involved various bond formations such as C-S and C-C which occurred with the help of nucleophilic substitution reaction. The last synthetic step involved palladium-catalyzed Suzuki coupling reaction to afford C-C bond formation.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Reference of 2-Furoic hydrazide, and with the development of science, more effects of this compound(3326-71-4) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Studies on Cycloalkane-Based Bisamide Organogelators: A New Example of Stochastic Chiral Symmetry-Breaking Induced by Sonication, the main research direction is cycloalkane based bisamide organogelator stochastic chiral symmetry breaking sonication; chirality; cycloalkane bisamides; physical asymmetric-induction; self-assembly; symmetry breaking; ultrasound.Safety of cis-Cyclohexane-1,2-dicarboxylic acid.

Enantiomerically pure C16-alkyl amides derived from cis and trans cycloalkane-1,2-dicarboxylic acids, resp., have been synthesized and their behavior as organogelators has been investigated. These compounds include cis/trans diastereomeric cyclobutane and cyclohexane derivatives with the aim to explore the influence of the ring size as well as the relative configuration in their hierarchical self-assembly to form gels. High resolution 1H NMR spectroscopy studies allowed the determination of the dynamics of the gelation process in [D8]toluene and the sol-gel transition temperature The morphol. and size of the aggregates have been investigated and results have shown that, in the case of cyclobutane derivatives, the cis/trans stereochem. is not relevant for the gelation behavior and the properties of the soft-materials obtained, but it is remarkable for cyclohexane diamides, which are better organogelators. The four compounds produce chiral aggregates despite that two of them are meso achiral mols. We show herein that this fact is an example of stochastic symmetry breaking induced by sonication. The self-assembly of these mols. has been modelled providing information and support about the structure and the chirality of the aggregates.

There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1[C@@H](C(O)=O)CCCC1)O)Safety of cis-Cyclohexane-1,2-dicarboxylic acid, and with the development of science, more effects of this compound(610-09-3) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about On the importance of antiparallel π-π interactions in the solid state of isatin-based hydrazides, the main research direction is hydrazone preparation crystal structure pi stacking interaction energy.Recommanded Product: 2-Furoic hydrazide.

The condensation of N-Pr isatin (1) with different carboxylic acid hydrazides (RCONHNH2 (2-6), R = arene) via sonication was used to synthesize five new hydrazones (7-11). Fully characterized mol. structures were further studied by single-crystal X-ray diffraction showing them to be Z-(syn-) form with respect to the hydrazoic C=N bond. In the crystal structures, hydrogen bonds and π-stacking interactions are described and analyzed by means of d. functional theory (DFT) calculations since they play a crucial role in the construction of three-dimensional supramol. frameworks. Moreover, the noncovalent interactions have been characterized using the NCIplot index. Remarkably, the π-system of the substituted isatin ring presents a dual character (acidic/basic), thus promoting the formation of the antiparallel π-stacking assemblies to maximize electron donor-acceptor π-π interactions. Moreover, interesting cooperativity effects have been studied since the presence of an intramol. H-bonding interaction enhances the strength of the π-π interactions as shown by DFT calculations

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Recommanded Product: 2-Furoic hydrazide, and with the development of science, more effects of this compound(3326-71-4) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Deciphering of Ligand-to-Metal Charge-Transfer Process: Synthesis, Spectroscopic and Theoretical Study, published in 2019, which mentions a compound: 3326-71-4, mainly applied to Schiff base metal ion sensing fluorescence density functional theory, Name: 2-Furoic hydrazide.

Many reports on metal ion sensing applications are available in literature but the mechanism of selectivity is not clear. Here the synthesis and characterization of a Schiff base Furan-2-carboxylic acid pyren-1-ylmethylene-hydrazide (PYFH) has been described with selective detection of copper(II) metal ion among different metal ions by UV-vis, fluorescence and HRMS spectroscopic methods. The S2- ion (Na2S) was added to the PYFH:Cu2+ complex for checking reversibility of PYFH by fluorescence, fluorescence microscopic imaging and mol. logic gate construction (combination of NOT and OR gate). From the exptl. findings the reason for selectivity of Cu2+ metal ion among a series of metal ions is not clear. So, to explore the causes of selectivity of Cu2+ metal ion by PYFH, D. Functional Theory (DFT) calculation was conducted for free PYFH and various sets of metal ions individually with PYFH. From DFT calculation it was understandable that selectivity of PYFH towards Cu2+ ions occurred due to lowering of HOMO-LUMO energy of PYFH:Cu2+ composites (-8.46 & -5.80 eV) compared to free PYFH (-5.56 & -2.15 eV). Whereas energy of HOMO and LUMO with other metals ions (PYFH:Mn+) are ∼-5.50 and ∼-2.24 eV resp., as a result PYFH does not get any extra stability.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Name: 2-Furoic hydrazide, and with the development of science, more effects of this compound(3326-71-4) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities, published in 2021, which mentions a compound: 3326-71-4, mainly applied to diethylaminocoumarinyl oxadiazole preparation acetylcholinesterase inhibition SAR docking; 1,3,4-oxadiazole; Coumarin; acetylcholinesterase inhibitor; molecular docking, Safety of 2-Furoic hydrazide.

Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives I [R = n-Bu, 2-thienyl, Ph, etc.] were synthesized via iodine-mediated oxidative cyclization and confirmed by 1H NMR, 13C NMR and HRMS. The synthesized derivatives I were tested against in-vitro acetylcholinesterase inhibitory activity and results showed that compounds I [R = 4-ClC6H4, 4-BrC6H4] exhibited moderate inhibitory activities with 69.19% and 65.06%, resp. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of Ph of compounds I could enhance their activities. Mol. docking study suggested that compound I [R = ClC6H4] possessed an optimal docking pose with interactions inside AChE.

If you want to learn more about this compound(2-Furoic hydrazide)Safety of 2-Furoic hydrazide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3326-71-4).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Computed Properties of C6H10O3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Selective hydrogenolysis of 2-furancarboxylic acid to 5-hydroxyvaleric acid derivatives over supported platinum catalysts. Author is Asano, Takehiro; Takagi, Hiroshi; Nakagawa, Yoshinao; Tamura, Masazumi; Tomishige, Keiichi.

The conversion of 2-furancarboxylic acid (FCA), which is produced by oxidation of furfural, to 5-hydroxyvaleric acid (5-HVA) and its ester/lactone derivatives with H2 was investigated. Monometallic Pt catalysts were effective, and other noble metals were not effective due to the formation of ring-hydrogenation products. Supports and solvents had a small effect on the performance; however, Pt/Al2O3 was the best catalyst and short chain alcs. such as methanol were better solvents. The optimum reaction temperature was about 373 K, and at higher temperature the catalyst was drastically deactivated by deposition of organic materials on the catalyst. The highest yield of target products (5-HVA, δ-valerolactone (DVL), and Me 5-hydroxyvalerate) was 62%, mainly obtained as Me 5-hydroxyvalerate (55% yield). The byproducts were mainly ring-hydrogenation compounds (tetrahydrofuran-2-carboxylic acid and its ester) and undetected ones (loss of carbon balance). The catalyst was gradually deactivated during reuses even at a reaction temperature of 373 K; however, the catalytic activity was recovered by calcination at 573 K. The reactions of various related substrates were carried out, and it was found that the O-C bond in the O-C=C structure (1,2,3-position of the furan ring) is dissociated before C=C hydrogenation while the presence and position of the carboxyl group (or methoxy carbonyl group) much affect the reactivity.

If you want to learn more about this compound(Methyl tetrahydrofuran-2-carboxylate)Computed Properties of C6H10O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(37443-42-8).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reaction of methyl tetrahydropyromucate with aniline. XXXI》. Authors are Yur’ev, Yu. K.; Vendel’shtein, E. G..The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).Recommanded Product: 37443-42-8. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Passage of Me 2-furoate in a H atm. over Pd-asbestos at 160° gave 78% Me tetrahydro-2-furoate, b736 179.5-80.5°, n20D 1.4371, d204 1.1080. This (10 g.) and 27 g. PhNH2 passed in a N atm. over Al2O3 at 360° gave CO2, 14 g. PhNH2, and 1.5 g. 1-phenylpyrrolidine, b4 104-5°, n20D 1.5840, d204 1.0164; picrate, m. 116°. Passage of the ester at 360° over Al2O3 in a N atm. gave CO2, propene, and MeOH. Hydrolysis of the ester with 2 N NaOH 4 hrs. at reflux gave 76% free acid, a sirupy microcrystalline mass; this heated to 270-80° begins to lose CO2, which occurs freely at 300-5°, yielding furanidine, b755 65°, n20D 1.4088, d204 0.8899.

If you want to learn more about this compound(Methyl tetrahydrofuran-2-carboxylate)Recommanded Product: 37443-42-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(37443-42-8).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics