Day: April 1, 2022

Yao, Lihong; Su, Chang’an; Chen, Xin; Qi, Liquan; Tie, Mei published the article 《Synthesis of the alkyl esters of α-furoic acid as flavors》. Keywords: furoic acid ester preparation flavoring material.They researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:37443-42-8) here.

The seven alkyl esters of α-furoic acid were synthesized in 80-95.6% yields by refluxing the solution of benzene (or toluene) containing 0.1 mol α-furoic acid and the corresponding aliphatic alcs. (0.12∼0.5 mol) for 3 h in the presence of p-toluenesulfonic acid (0.01 mol) and 5 mL 30% hydrogen peroxide.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies.COA of Formula: C5H6N2O2.

Synthesis of new (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamide derivatives I [R = H, 5-Br, 3-NO2, etc.] via p-TSA catalyzed reaction between isatoic anhydride, 2-furoic hydrazide and substituted salicylaldehydes in ethanol:water (5:5 volume/volume) solvent system under ultrasound irradiation at room temperature was carried out. The important features of this protocol were simple and easy workup procedure, reaction carried out at ambient temperature, use of ultrasound and high yield of (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides in short reaction time. The synthesized compounds I were screened against tyrosinase enzyme and all these compounds found to be potent inhibitors with much lower IC50 value of 0.028 ± 0.016 to 1.775 ± 0.947 μM than the standard kojic acid (16.832 ± 1.162 μM). The kinetics mechanism for compound I [R = 3,5-di-Br] was analyzed by Lineweaver-Burk plots which revealed that compound inhibited tyrosinase non-competitively by forming an enzyme-inhibitor complex. Along with this all the synthesized compounds I were scanned for their DPPH free radical scavenging ability. The outputs received through in vitro and in silico anal. were coherent to the each other with good binding energy values (kcal/mol) posed by synthesized ligands.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Aydin, Duygu; Gunay, Ibrahim Berk; Karuk Elmas, Sukriye Nihan; Savran, Tahir; Arslan, Fatma Nur; Sadi, Gokhan; Yilmaz, Ibrahim published the article 《A simple and sensitive fluorescent sensor platform for Al3+ sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: practical applications in drinking water and bio-imaging》. Keywords: fluorescent sensor aluminum bioimging.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Product Details of 3326-71-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

In this study, a novel hydrazide-based compound, (E)-N′-(5-(benzo[d]thiazol-2-yl)-2-hydroxybenzylidene)furan-2-carbohydrazide (probe BOTH, I) was designed, characterized and prepared as a fluorogenic “”turn-on”” sensor for monitoring Al3+ in near-perfect aqueous media. All emission and absorbance spectral studies were performed in HEPES/DMSO (volume/volume, 99.95/0.05, pH = 7.0) media at 25 °C. The quantum yield of probe BOTH increases considerably in the presence of Al3+. Probe BOTH could sense Al3+ at a concentration as low as 6.47 nM. Probe BOTH could sense Al3+ with high sensitivity and selectivity, and a quant. correlation of R2 = 0.9887 in the Al3+ concentration range of 0.0-20.0 equivalent To evaluate the method parameters, a validation study was performed based on different anal. parameters. The formation of complex BOTH-Al3+ (2 : 1 stoichiometry) was confirmed by 1H-NMR titration and MALDI-TOF MS, as well as Job′s methods. pH-Dependent and Benesi-Hildebrand plot studies also supported this proposed sensing mechanism. Besides, the binding mechanism of Al3+ with probe BOTH was further verified by theor. studies. Moreover, probe BOTH could be used for monitoring Al3+ in living-cells and water samples.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Rani Gupta, Shraddha; Yadav, Pranjalee; Singh, Priya; Koch, Biplob; Singh, Vinod P. published the article 《A “”Turn-On”” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies》. Keywords: lung cancer aluminum water soluble fluorescent probe furan.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Safety of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

A furan-based water soluble fluorescent probe (E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1H NMR, 13C NMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “”turn-on”” fluorescence response towards Al3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo-induced electron transfer) and C=N isomerization. 1 : 1 stoichiometric ratio between DBF and Al3+ was rationalized by Job′s plot. Binding constant and LOD were calculated to be 1.031×105 M-1 and 6.34×10-8 M, resp. MTT assay on live A549 cells indicated no serious cytotoxicity in the cells even at higher concentration Further, DBF was successfully used for the detection of accumulated Al3+ in the cytoplasm of cells.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 610-09-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about An Open-Framework Material with Dangling Organic Functional Groups in 24-Ring Channels. Author is Zhu, Jin; Bu, Xianhui; Feng, Pingyun; Stucky, Galen D..

An open-framework material with dangling organic functional groups in 24-ring channels, Zn3(O3PCH2CO2)2(O3PCH2CO2H)(NH3CH2CH2NH3)(BTC) (BTC = 1,3,5-benzenetricarboxylic acid), was prepared and its crystal structure was determined The material with a tetrahedral zeolite-type structure belongs to space group R3̅, Z = 18, a 41.663(7), c 7.843(2)Å, R = 7.43, Rw = 19.7%. Each O3PCH2CO2 group behaves like a regular PO43- group in zeolite-type frameworks and is 4-connected to 4 Zn sites; 2 of the 3 unique Zn sites are 4-connected to P atoms sites. The 3rd Zn site is pentacoordinated to 5 O atoms and 3-connected to P sites because 2 pairs of O atoms are chelating O atoms from 2 O3PCH2CO2 groups.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Singh, Dharmender; Tiwari, Sandip Kumar; Singh, Virender published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).HPLC of Formula: 3326-71-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

An efficient protocol were developed for one-pot synthesis of biol. interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C-O bond formation strategy. This metal-free sequential approach was found to be compatible with diversely substituted 1-formyl β-carbolines and aromatic as well as aliphatic hydrazides, providing access to a variety of multifunctional β-carboline linked 1,3,4-oxadiazole derivatives in good to excellent yields. The methodol. was found to be applicable to gram scale synthesis of β-carboline substituted 1,3,4-oxadiazole derivatives Addnl., β-carboline C1 linked 2-amino-1,3,4-oxadiazoles and bis-1,3,4-oxadiazoles were also synthesized using the same strategy.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Phosphine-Free Ruthenium Complex-Catalyzed Synthesis of Mono- or Dialkylated Aryl Hydrazides via the Borrowing Hydrogen Strategy, the main research direction is aryl hydrazide alkylation alc ruthenium catalyst.Formula: C5H6N2O2.

A diaminocyclopentadienone ruthenium tricarbonyl complex-catalyzed synthesis of mono- or dialkylated aryl hydrazides from N-unsubstituted aryl hydrazides and various substituted primary and secondary alcs. as alkylating reagents using the borrowing hydrogen strategy has been developed. Deuterium labeling experiments confirmed that the alcs. are the hydride source in this cascade process. D. functional theory (DFT) calculations unveiled the origin and the threshold between the mono- and dialkylation.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Formula: C5H6N2O2, and with the development of science, more effects of this compound(3326-71-4) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Azerbaidzhanskii Khimicheskii Zhurnal called Stereochemistry of cyclic dicarboxylic acids studies by potentiometric titration. IV. Effect of the composition and dielectric constant of acetone-water solutions on the ionization constants of cis- and trans-1,2-dicarboxylic acids, Author is Salakhov, M. S.; Israfilov, A. I.; Shamilov, T. O., which mentions a compound: 610-09-3, SMILESS is O=C([C@H]1[C@@H](C(O)=O)CCCC1)O, Molecular C8H12O4, Computed Properties of C8H12O4.

Ionization constants of cis and trans isomers of 1,2-cyclohexanedicarboxylic acid, 4-cyclohexene-1,2-dicarboxylic acid, 1-methyl-4-cyclohexene-1,2-dicarboxylic acid, 5-norbornene-2,3-dicarboxylic acid, and 1,2,3,4,9,9-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene-2,3-dicarboxylic acid, cis-3-methyl-4-cyclohexene-1,2-dicarboxylic acid, and cis-4,5-dimethyl-4-cyclohexene-1,2-dicarboxylic acid were determined and correlated with configuration and solvent composition

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Kolbe electrolyses of cis- and trans-methyl hydrogen hexahydrophthalate, published in 1956, which mentions a compound: 610-09-3, Name is cis-Cyclohexane-1,2-dicarboxylic acid, Molecular C8H12O4, HPLC of Formula: 610-09-3.

The Kolbe electrolysis of cis- and trans-Me H hexahydrophthalate (I) in anhydrous MeOH has been carried out. Identical mixtures of uncoupled products were obtained from both isomers. Me 1-cyclohexene- and 2-cyclohexene-1-carboxylate and Me cyclohexanecarboxylate were obtained as monomeric products. Dimeric materials were obtained for the first time from I. Saponification of the dimeric ester mixture gave 2 perhydrodiphenic acids, trans-anti-trans and trans-syn-trans, which were separated and identified quantitatively by adsorption chromatography and infrared analysis. Since epimerization occurred on all centers α to the carboxyl group, no conclusion about the stereochemistry of the radicals could be deduced from the ratios of coupled products.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application In Synthesis of 2-Furoic hydrazide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions. Author is Lu, Fangling; Gong, Fengping; Li, Liangsen; Zhang, Kan; Li, Zhen; Zhang, Xinwei; Yin, Ying; Wang, Ying; Gao, Ziwei; Zhang, Heng; Lei, Aiwen.

1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive mols. In this study, intermol. electrochem. cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91% [e.g., benzohydrazide + 2-oxo-2-phenylacetic acid → 2,5-diphenyl-1,3,4-oxadiazole (90%)]. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics