Day: April 11, 2022

Reference of 2-Furoic hydrazide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino-1,3,4-thiadiazoles. Author is Prasad, Malavattu G.; Lakshmi, Chapala V.; Katari, Naresh K.; Pal, Manojit.

An ultrasound-assisted method facilitated by lemon juice has been developed to synthesize 2-amino-1,3,4-thiadiazole derivatives I (Ar = Ph, 2-methoxy-5-nitrophenyl, pyridin-3-yl, etc.) that could act as potential anticancer agents. Accordingly, a convenient method has been developed for the rapid synthesis of this class of compounds I under a mild and non-hazardous reaction condition in good yields. The methodol. involved the reaction of various acid hydrazides ArC(O)NHNH2 with TMSNCS in the presence of lemon juice in PEG-400 at room temperature (25-30°C) under ultrasound irradiation These compounds I were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g., MDAMB-231 and MCF-7 and subsequently against SIRT1. The 2-amino 1,3,4-thiadiazole derivatives I (Ar = 4-methoxyphenyl, 3-methoxyphenyl, 2,3-dimethoxyphenyl, 2-methoxy-5-nitrophenyl) showed promising growth inhibition of MDAMB- 231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, I (Ar = 3-methoxyphenyl) was found to be a potent inhibitor of SIRT1.

There are many compounds similar to this compound(3326-71-4)Reference of 2-Furoic hydrazide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Gamov, G. A.; Khodov, I. A.; Belov, K. V.; Zavalishin, M. N.; Kiselev, A. N.; Usacheva, T. R.; Sharnin, V. A. published the article 《Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution》. Keywords: pyridoxal phosphate hydrazone conformer hydrolysis kinetics overhauser effect.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Application of 3326-71-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chem. calculations and NOE experiment The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from exptl. and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV-Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6-7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1H, 13C, 31P NMR, IR, UV-Vis, fluorescent, MS-spectroscopy as well as DSC and elemental anal.

There are many compounds similar to this compound(3326-71-4)Application of 3326-71-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Stereoisomeric biologically active compounds. I. Some conversions of cis-4-chloro-4-cyclohexene-1,2-dicarboxylic acid》. Authors are Rashidyan, L. G.; Tatevosyan, G. T..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Category: benzisoxazole. Through the article, more information about this compound (cas:610-09-3) is conveyed.

cf. Baeyer, Ann. Chem. 258, 215(1890); U.S. 1,967,862, CA 28, 5994. To 10 g. cis-4-chloro-4-cyclohexene-1,2-dicarboxylic acid (I) and 60 ml. H2O, under cooling and stirring, a solution of 21 g. KMnO4 in 650 650 ml. H2O was added over 3 hrs. The cooling and stirring was another 2 hrs. and the mixture left standing overnight, yielding meso-butane-1,2,3,4-tetracarboxylic acid m. 191-2°. I (204.5 g.) and 15 ml. concentrated H2SO4 in 500 ml. absolute MeOH was refluxed for 8 hrs. Dimethyl cis-4-chloro-4-cyclohexene-1,2-dicarboxylate (II), b5 148-50°, d204 1.0553, n20D 1.4935 was obtained in 71.3% yield. II (20 g.) and 18 ml. 85% H2NNH2 was refluxed for 3 hrs. Trans-4-chloro-4-cyclohexene-1,2-dicarboxylic acid dihydrazide (III) m. 222-4° (60% EtOH) was obtained in 69.5% yield. To 30 g. III in 105 ml. 10% HCl and 280 ml. CH2Cl2 at 18-20°, a solution of 20.8 g. NaNO3 in 48.5 ml. H2O was slowly added. The nonaqueous layer was dried, filtered, and treated with 160 ml. absolute EtOH. The CH2Cl2 was evaporated, the mixture refluxed for 2 hrs., 210 ml. 40% NaOH added and steam distilled The distillate was acidified with 10% HCl giving the trans-4-chloro-1,2-diamino-4-cyclohexene-2HCl m. 326-8° in 72.1% yield. III (38 g.) and a solution of 26.6 g. NaOH in 350 ml. H2O was refluxed for 12 hrs. and acidified, giving trans-4-chloro-4-cyclohexene-1,2-dicarboxylic acid (IV) m. 115-17° (H2O) in 89.8% yield. IV (10 g.) was oxidized with KMnO4 as described above, giving the dianhydride of dl-butane-1,2,3,4-tetracarboxylic acid m. 172-3°. A solution of 21 g. IV, 8 g. NaOH and 70 ml. H2O was hydrogenated in an autoclave in the presence of 35 g. Ni on Cr2O3 at 100° and 100 atm. The solution was filtered and acidified giving trans-cyclohexane-1,2-dicarboxylic acid (V) m. 220° (Me2O) in 78.2% yield. I (60 g.) and 23.5 g. NaOH in 200 ml. H2O was hydrogenated as described above giving cis-cyclohexane-1,2-dicarboxylic acid (VI), m. 192°, in 92.1% yield. A mixture of 8 g. VI and 20 ml. concentrated HCl was heated in a sealed tube at 180° for 8-10 hrs. and V, m. 220-1°, was obtained in 88.8% yield.

There are many compounds similar to this compound(610-09-3)Category: benzisoxazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, and nonlinear optical properties of some new series of S-(5-aryl-1,3,4-oxadiazol-2-yl)-2-chloroethanethioate derivatives, published in 2019, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Electric Literature of C5H6N2O2.

In the present investigation, some novel S-(5-aryl-1,3,4-oxadiazol-2-yl)-2-chloroethanethioate I [Ar = Ph, 2-ClC6H4, 2-furanyl, 2-O2NC6H4, 3-O2NC6H4] derivatives were synthesized and their impact on optical properties was studied. The nonlinear refractive indexes of compounds I were also measured in dichloromethane via Z-scan method using a continuous wave diode-pumped laser at 532 nm wavelength. The nonlinear refractive coefficient of compounds I was obtained from 1011 m2/W order. Regarding the appropriate nonlinearity of these compounds, they could be considered good candidates for biooptical and photonic applications. All the synthesized compounds I were also evaluated for their antibacterial and antifungal activities. The bioactive assay showed that the synthetic compounds displayed variable inhibition zones against tested bacterium Escherichia coli and fungus Aspergillus fumigatus in comparison to enrofloxacin and amphotericin as reference drugs, which are normally used for treating such infections. Synthesized compounds were characterized by elemental anal. and various spectroscopic methods including FTIR, 1H NMR, 13C NMR and UV-Vis techniques.

There are many compounds similar to this compound(3326-71-4)Electric Literature of C5H6N2O2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 610-09-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about An Open-Framework Material with Dangling Organic Functional Groups in 24-Ring Channels. Author is Zhu, Jin; Bu, Xianhui; Feng, Pingyun; Stucky, Galen D..

An open-framework material with dangling organic functional groups in 24-ring channels, Zn3(O3PCH2CO2)2(O3PCH2CO2H)(NH3CH2CH2NH3)(BTC) (BTC = 1,3,5-benzenetricarboxylic acid), was prepared and its crystal structure was determined The material with a tetrahedral zeolite-type structure belongs to space group R3̅, Z = 18, a 41.663(7), c 7.843(2)Å, R = 7.43, Rw = 19.7%. Each O3PCH2CO2 group behaves like a regular PO43- group in zeolite-type frameworks and is 4-connected to 4 Zn sites; 2 of the 3 unique Zn sites are 4-connected to P atoms sites. The 3rd Zn site is pentacoordinated to 5 O atoms and 3-connected to P sites because 2 pairs of O atoms are chelating O atoms from 2 O3PCH2CO2 groups.

There are many compounds similar to this compound(610-09-3)SDS of cas: 610-09-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.COA of Formula: C6H13NO. The article 《Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:3326-71-4).

An oxidative sp3 C-H bond of methyl-azaheteroarenes protocol RCH3 (R = quinolin-2-yl, benzo[f]quinolin-3-yl, pyridin-2-yl, etc.) was reported for the synthesis of 1,3,4-oxadiazoles I (R1 = 2H-1,3-benzodioxol-5-yl, furan-2-yl, prop-1-en-2-yl, etc.) via [4+1] annulation with hydrazides R1C(O)NHNH2. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles I via selective oxidation of sp3 C-H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

There are many compounds similar to this compound(3326-71-4)Computed Properties of C5H6N2O2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 610-09-3, is researched, Molecular C8H12O4, about Synthesis and properties of some basic metals and manganese salts of cis-1,2-cyclohexane dicarboxylic acid, the main research direction is transition metal cyclohexanedicarboxylate preparation; wheat fertilizer liver inhibition transition metal cyclohexanedicarboxylate.Application of 610-09-3.

Sodium, potassium, ammonium and manganese salts of cis-1,2-cyclohexanedicarboxylic acid were synthesized. The structural characteristics of these salts were analyzed by thermog. and spectroscopic methods and examined on liver and wheat under the effect of their biol. activities. They can be used as a micro-fertilizer in the fields biol. and agriculture.

There are many compounds similar to this compound(610-09-3)Application of 610-09-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Chemistry of Heterocyclic Compounds (New York, NY, United States) called The synthesis of 3-(het)aryl-6,7-dihydro-5H-[1,2,4]-triazolo[3,4-a][2]benzazepines, Author is Glushkov, Vladimir A.; Babentsev, Dmitry N.; Dmitriev, Maksim V.; Stepanova, Kseniya A.; Kharintseva, Anastasiya Yu.; Simakhina, Anastasiya E., the main research direction is aryldihydrotriazolobenzazepine preparation; benzazepine hydrazide cyclization.Safety of 2-Furoic hydrazide.

4-Aryl-2-methylbutan-2-ols with methoxy or methylenedioxy substituents participate in the Graf-Ritter reaction with Me thiocyanate in the presence of an acid (H2SO4, MeSO3H) forming 1-methylsulfanyl-2-benzazepines in low yields (11-35%), which underwent cyclization with benzhydrazide or hetarenecarboxylic acid hydrazides upon reflux in o-dichlorobenzene into the corresponding 3-phenyl- and 3-hetaryl-6,7-dihydro-5H-1,2,4-triazolo[3,4-a][2]benzazepines I (R1 = R2 = OMe, R1+R2 = OCH2O; R3 = H, OMe; R4 = Ph, 2-furyl, 2-thienyl, 4-pyridyl) (45-74% yields).

There are many compounds similar to this compound(3326-71-4)Safety of 2-Furoic hydrazide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensation of aromatic aldehydes with glycine and acetylglycine》. Authors are Dakin, H. D..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).HPLC of Formula: 610-09-3. Through the article, more information about this compound (cas:610-09-3) is conveyed.

The condensation referred to in the title is complicated by a competing reaction between CH2(NH2)CO2H and BzH, forming a non-acetylated derivative possibly of a type resembling a Schiff base. The 2 reactions are shown thus: (1) H2NCH2CO2H → AcNHCH2CO2H → MeC:N.C(:CHPh).CO.O → MeCONHC(:CHPh)CO2H, (2) HO2CCH2NH2 + BzH → HO2CCH2N:-CHPh (I) or O.CO.CH2.NH.CHPh. I may be called benzylideneglycine and was isolated and analyzed. Because the 2nd condensation product is a non-acetylated compound its formation can be largely suppressed by acetylating the glycine before the reaction. Correspondingly larger yields of the azlactone of α-acetamidocinnamic acid were obtained. Acetylation was most easily effected by warming glycine suspended in 3 parts of glacial AcOH with the theoretical amount of Ac2O until solution was obtained. A variety of aldehydes was used although the product from salicyl aldehyde was the most interesting. AcOC6H4CH:C.N:CMe.O.CO (II) → HOC3H4CH:C(NHAc)CO2H (III) → O.C6H4.CH:C(NHAc).CO (IV). II on treating with alkali and subsequent acidification forms the transient III which quickly passes over to IV. Detailed exptl. data are given.

There are many compounds similar to this compound(610-09-3)HPLC of Formula: 610-09-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Modification of Monocarboxylic Acid Hydrazides with Tropylium Salts, published in 2019-12-31, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Recommanded Product: 3326-71-4.

Nicotinic, isonicotinic, and furan-2-carboxylic acid hydrazides reacted with 2 equiv of tropylium perchlorate or tetrafluoroborate to give the corresponding N’N’-di(cyclohepta-2,4,6-trein-1-yl) derivatives as a result of electrophilic substitution of both hydrogen atoms in the primary amino group. The reaction of furan-2-carbohydrazide with an equimolar amount of tropylium salt gave N’-(cyclohepta-2,4,6-trien-1-yl)furan-2-carbohydrazide.

There are many compounds similar to this compound(3326-71-4)Recommanded Product: 3326-71-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics