Day: April 12, 2022

Shang, Zhi-Hao; Sun, Ji-Na; Guo, Jiang-Shan; Sun, Yuan-Yuan; Weng, Wei-Zhao; Zhang, Zhen-Xiao; Li, Zeng-Jing; Zhu, Yan-Ping published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Reference of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

An oxidative sp3 C-H bond of methyl-azaheteroarenes protocol RCH3 (R = quinolin-2-yl, benzo[f]quinolin-3-yl, pyridin-2-yl, etc.) was reported for the synthesis of 1,3,4-oxadiazoles I (R1 = 2H-1,3-benzodioxol-5-yl, furan-2-yl, prop-1-en-2-yl, etc.) via [4+1] annulation with hydrazides R1C(O)NHNH2. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles I via selective oxidation of sp3 C-H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Ghezelbash, Zahra Dono; Motiei, Hamideh; Mahmoody, Miri; Dilmaghani, Karim Akbari published the article 《Synthesis, characterization, and nonlinear optical properties of some new series of S-(5-aryl-1,3,4-oxadiazol-2-yl)-2-chloroethanethioate derivatives》. Keywords: aryl oxadiazolyl chloroethanethioate preparation nonlinear optical property antibacterial antifungal; substituted oxadiazolethione preparation; acyl hydrazide preparation.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Recommanded Product: 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

In the present investigation, some novel S-(5-aryl-1,3,4-oxadiazol-2-yl)-2-chloroethanethioate I [Ar = Ph, 2-ClC6H4, 2-furanyl, 2-O2NC6H4, 3-O2NC6H4] derivatives were synthesized and their impact on optical properties was studied. The nonlinear refractive indexes of compounds I were also measured in dichloromethane via Z-scan method using a continuous wave diode-pumped laser at 532 nm wavelength. The nonlinear refractive coefficient of compounds I was obtained from 1011 m2/W order. Regarding the appropriate nonlinearity of these compounds, they could be considered good candidates for biooptical and photonic applications. All the synthesized compounds I were also evaluated for their antibacterial and antifungal activities. The bioactive assay showed that the synthetic compounds displayed variable inhibition zones against tested bacterium Escherichia coli and fungus Aspergillus fumigatus in comparison to enrofloxacin and amphotericin as reference drugs, which are normally used for treating such infections. Synthesized compounds were characterized by elemental anal. and various spectroscopic methods including FTIR, 1H NMR, 13C NMR and UV-Vis techniques.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Name: 2-Furoic hydrazide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer. Author is Ferreira, Ricardo J.; Gajdacs, Mario; Kincses, Annamaria; Spengler, Gabriella; dos Santos, Daniel J. V. A.; Ferreira, Maria-Jose U..

Naringenin (1), isolated from Euphorbia pedroi, was previously derivatized yielding compounds 2-13. In this study, aiming at expanding the pool of analogs of the flavanone core towards better multidrug resistance (MDR) reversal agents, alkylation reactions and chem. modification of the carbonyl moiety was performed (15-39). Compounds structures were assigned mainly by 1D and 2D NMR experiments Compounds 1-39 were assessed as MDR reversers, in human ABCB1-transfected mouse T-lymphoma cells, overexpressing P-glycoprotein (P-gp). The results revealed that O-methylation at C-7, together with the introduction of nitrogen atoms and aromatic moieties at C-4 or C-4′, significantly improved the activity, being compounds 27 and 37 the strongest P-gp modulators and much more active than verapamil. In combination assays, synergistic interactions of selected compounds with doxorubicin substantiated the results. While mol. docking suggested that flavanone derivatives act as competitive modulators, mol. dynamics showed that dimethylation promotes binding to a modulator-binding site. Moreover, flavanones may also interact with a vicinal ATP-binding site in both nucleotide-binding domains, hypothesizing an allosteric mode of action.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Product Details of 3326-71-4.Mu, Xinyue; Shi, Liping; Yan, Liqiang; Tang, Ningli published the article 《A 2-Hydroxy-1-naphthaldehyde Schiff Base for Turn-on Fluorescence Detection of Zn2+ Based on PET Mechanism》 about this compound( cas:3326-71-4 ) in Journal of Fluorescence. Keywords: zinc hydroxynaphthaldehyde Schiff base fluorescence cell imaging; Cell imaging; Fluorescence analysis; Schiff base; Water sample; Zn2+. Let’s learn more about this compound (cas:3326-71-4).

Zinc ion is closely related to human health. Its content in human body is small, while the effect is large. However, it is not the more the better, must be in a scientific balance. Therefore, it is significant to the rapid detection of Zn2+ in the environment and organism. Herein, a fluorescent probe based on 2-hydroxy-1-naphthalene formaldehyde and furan-2-carbohydrazide was conveniently synthesized via Schiff base reaction. And this probe has been successfully applied to the accurate and quant. detection of Zn2+ in real samples, showing turn on fluorescence, good selectivity, very low detection limit, real time response and reusability. In addition, this probe has the potential application to trace Zn2+ in living cells with low cytotoxicity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Carbohydrate Research called Hydrolysis and interactions of D-cellobiose with polycarboxylic acids, Author is Amarasekara, Ananda S.; Wiredu, Bernard; Lawrence, Yen Maroney, which mentions a compound: 610-09-3, SMILESS is O=C([C@H]1[C@@H](C(O)=O)CCCC1)O, Molecular C8H12O4, Computed Properties of C8H12O4.

The hydrolysis of cellulose model compound D-cellobiose was studied with a series of eight common polycarboxylic acids and two monocarboxylic acids in aqueous medium using 0.500 mmol -COOH/L at 170 °C. The maleic acid showed the highest catalytic activity with turnover frequency (TOF) of 29.5 h-1. The interaction of carboxylic acids with D-cellobiose in DMSO-d6 was studied by determination of the pseudo first-order rate constant kH of anomeric -OH exchange rate in cellobiose using 1H NMR spectroscopy. The maleic, oxalic and citric acids showed infinitely large kH values indicating very strong interactions with D-cellobiose. The next highest interactions were found with phthalic acid (kH = 248.8 Hz). The FT-IR studies showed significant carboxylic acid C=O stretching frequency shifts (ΔνC=O) of 12, 13 and 10 cm-1 for maleic, oxalic and acetic acids resp. in mixtures with D-cellobiose.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Yang, Min; Chen, Jing; He, Chen; Hu, Xin; Ding, Yechun; Kuang, Ying; Liu, Jinbiao; Huang, Qitong published an article about the compound: Methyl 2,4-dichloronicotinate( cas:442903-28-8,SMILESS:ClC1=C(C(=O)OC)C(=CC=N1)Cl ).Application of 442903-28-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:442903-28-8) through the article.

An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophys. property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Photochemical transformations. XI. Isomerization of 1,3-cyclooctadiene》. Authors are Dauben, William G.; Cargill, Robert L..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).SDS of cas: 610-09-3. Through the article, more information about this compound (cas:610-09-3) is conveyed.

cf. CA 54, 22718a. Com. 1,3-cyclooctadiene (I, n2D0 1.4940, λ 228 mμ (ε 5470, alc.), 22.1 g.) in 2 l. dry Et2O irradiated 200 hrs. with a Hanovia high pressure Hg arc lamp, internal probe, type L with magnetic stirring (He atm.), the progress of irradiation followed by ultraviolet spectroscopy to disappearance of I, the Et2O evaporated at 40-50° through a 1 ft. Vigreux column, and the yellow residue distilled through a Nester-Faust 2 ft. spinning band column gave 36-41% bicyclo[4.2.0]oct-7-ene (II), C8H12, b. 131-2°, n2D0 1.4720, λ205 mμ (ε 700, alc.), nuclear magnetic resonance singlets at 4.04 and complex multiplets at 7.21, 8.47 τ, infrared spectrum identical with that of material prepared from cyclooctatetraene dibromide. NaIO4 (9.78 millimoles), 0.16 millimole KMnO4, and 0.37 millimole K2CO3 in 200 ml. H2O stirred 25 hrs. at 25° with 1.03 millimoles II, the mixture acidified with 15% H2SO4, extracted 20 hrs. with Et2O, the dried extract evaporated, and the residue triturated with petr. ether gave 105 mg. solid, recrystallized from H2O and from Et2O-petr. ether to give cis-1,2-cyclohexanedicarboxylic acid, m. 197.5-8.0°. At no time was the typical spectrum of 1,3,5-hexatriene detected in the ultraviolet absorption spectrum of the irradiated solution

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chlorination of tetrahydrofuran-2-carboxylic acid esters, published in 1979-02-28, which mentions a compound: 37443-42-8, mainly applied to chlorination photochem furancarboxylate; furancarboxylate tetrahydro chlorination; chlorotetrahydrofurancarboxylate, Synthetic Route of C6H10O3.

Photochem. chlorination of Me tetrahydro-2-furancarboxylate in CCl4 at -15 to -20° gave the chlorofurancarboxylate I and small amounts of the dihydrofuran II (8%) and Me 2-furancarboxylate (2%). Et tetrahydro-2-furancarboxylate was similarly chlorinated. The by-products were formed by dehydrochlorination of intermediate x-chlorination products.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Glushkov, Vladimir A.; Babentsev, Dmitry N.; Dmitriev, Maksim V.; Stepanova, Kseniya A.; Kharintseva, Anastasiya Yu.; Simakhina, Anastasiya E. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Product Details of 3326-71-4.They published the article 《The synthesis of 3-(het)aryl-6,7-dihydro-5H-[1,2,4]-triazolo[3,4-a][2]benzazepines》 about this compound( cas:3326-71-4 ) in Chemistry of Heterocyclic Compounds (New York, NY, United States). Keywords: aryldihydrotriazolobenzazepine preparation; benzazepine hydrazide cyclization. We’ll tell you more about this compound (cas:3326-71-4).

4-Aryl-2-methylbutan-2-ols with methoxy or methylenedioxy substituents participate in the Graf-Ritter reaction with Me thiocyanate in the presence of an acid (H2SO4, MeSO3H) forming 1-methylsulfanyl-2-benzazepines in low yields (11-35%), which underwent cyclization with benzhydrazide or hetarenecarboxylic acid hydrazides upon reflux in o-dichlorobenzene into the corresponding 3-phenyl- and 3-hetaryl-6,7-dihydro-5H-1,2,4-triazolo[3,4-a][2]benzazepines I (R1 = R2 = OMe, R1+R2 = OCH2O; R3 = H, OMe; R4 = Ph, 2-furyl, 2-thienyl, 4-pyridyl) (45-74% yields).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organic Chemistry called Kolbe electrolyses of cis- and trans-methyl hydrogen hexahydrophthalate, Author is Overberger, C. G.; Kabasakalian, Peter, which mentions a compound: 610-09-3, SMILESS is O=C([C@H]1[C@@H](C(O)=O)CCCC1)O, Molecular C8H12O4, Computed Properties of C8H12O4.

The Kolbe electrolysis of cis- and trans-Me H hexahydrophthalate (I) in anhydrous MeOH has been carried out. Identical mixtures of uncoupled products were obtained from both isomers. Me 1-cyclohexene- and 2-cyclohexene-1-carboxylate and Me cyclohexanecarboxylate were obtained as monomeric products. Dimeric materials were obtained for the first time from I. Saponification of the dimeric ester mixture gave 2 perhydrodiphenic acids, trans-anti-trans and trans-syn-trans, which were separated and identified quantitatively by adsorption chromatography and infrared analysis. Since epimerization occurred on all centers α to the carboxyl group, no conclusion about the stereochemistry of the radicals could be deduced from the ratios of coupled products.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics