Day: April 15, 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Iodine-promoted one-pot synthesis of 1,3,4-oxadiazole scaffolds via sp3 C-H functionalization of azaarenes.Recommanded Product: 2-Furoic hydrazide.

An efficient iodine-mediated one-pot synthetic protocol for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles scaffolds I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = 2-pyridyl, 2-quinolinyl, 7-Clquinolin-2-yl, etc.] was developed via sp3 C-H functionalization. This method involved oxidative amination with concomitant base-mediated cyclization of methylhetarenes and acylhydrazines by employing iodine and Cs2CO3. The key features of the present method included good functional group tolerance, a clean protocol, metal-free conditions and high yields, making this protocol an attractive strategy toward the synthesis of bioactive mols. and their key building blocks.

In some applications, this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

COA of Formula: C8H12O4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about 3,8-Thionanedione 1,1-dioxide. Synthesis and solid-state conformation. Author is Quin, Louis D.; Leimert, John; Middlemas, Eric D.; Miller, Richard W.; McPhail, Andrew T..

The title compound is conventiently prepared in 80% overall yield by ozonolysis at -78°C of the cycloadduct of SO2 with 1,2-dimethylenecyclohexane. Single-crystal X-ray anal. establishes that the nine-membered ring adopts a twist-chair-chair conformation in which the S and the mid-point of the C(5)-C(6) bond lie on a noncrystallog. C2 axis, but the ring shape differs significantly from that of cyclononane in order to accommodate transannular dipole…dipole interactions.

In some applications, this compound(610-09-3)COA of Formula: C8H12O4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives, the main research direction is amino oxadiazole preparation; isothiocyanate hydrazide potassium catalyst intramol cyclization desulfurization green chem.Quality Control of 2-Furoic hydrazide.

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles were established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room temperature and produced corresponding products in moderate to good yields. This protocol also showed good functional group tolerance.

In some applications, this compound(3326-71-4)Quality Control of 2-Furoic hydrazide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Name: 2-Furoic hydrazide.Yu, Xiang; Yang, Wude; Huang, Ling; Zhou, Xingji; Chen, Yafang published the article 《Preparation and acetylcholinesterase inhibitory activities of pyridine-based 1,3,4-oxadiazole derivatives》 about this compound( cas:3326-71-4 ) in Heterocycles. Keywords: pyridinyl oxadiazole preparation acetylcholinesterase inhibition SAR docking. Let’s learn more about this compound (cas:3326-71-4).

Fourteen pyridine-based 1,3,4-oxadiazole derivatives I [R = n-Bu, Ph, 3-pyridyl, etc.] were synthesized from pyridine-2-carboxaldehyde via iodine-mediated oxidative cyclization with substituted hydrazides by using the impregnation method. Their structures were confirmed by m.p., 1H NMR, 13C NMR and HRMS. Preliminary bioassay of these derivatives I, inhibition of acetylcholinesterase (AChE) was also evaluated in-vitro at the concentration of 1μmol/mL. The result showed that compounds I [R = 3-methoxyphenyl, 3-pyridyl, 4-pyridyl] had moderate inhibitory activities with 52%, 59% and 59%, resp. The preliminary structure-activity relationships revealed that the introduction of pyridine ring could enhance the activity. Mol. docking study demonstrated that compound I [R = 4-pyridyl] possessed an optimal docking pose with interactions at the middle of the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE.

In some applications, this compound(3326-71-4)Name: 2-Furoic hydrazide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Synthesis of acylhydrazone based fluorescent probe for Al (III) and its property, the main research direction is acylhydrazone fluorescent probe aluminum fluorometry.SDS of cas: 3326-71-4.

An acylhydrazone based fluorescent probe was synthesized by two-step reaction with tetrakis(bromomethyl) benzene and 2,4-dihyoxybenzaldehyde as raw materials. The compound showed excellent selectivity for Al3+ in the V(DMSO):V (H2O) = 19:1 solution, showing remarkable fluorescence enhancement effects towards Al3+ at the emission wavelength of 446 nm. The stoichiometry of 1:2 of the Al (III) complexes was determined by Job’s plots, 1HNMR titration experiments and LC-MS anal. The spectroscopic titration indicated that the detection limits of the probe for Al3+ were 1.16 × 10-7 mol/L and the complexing constant of the probe to Al3+ was 2.28 × 10-3 L/mol. Furthermore, the probe can be used for the determination of Al3+ in the river water and tap water samples.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Sandeep, Thummar; Vasishta, Bhatt published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Reference of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

A series of (((oxadiazolyl-thio)(nitrophenyl-amino)pyrimidinyl)hydrazinyl)-N-phenylacetamide motifs I [R = Ph, 2-furyl, 3-pyridyl, etc.] was synthesized and studied for their antibacterial and antifungal activities as well as for mol. docking and FMO studies. All the synthesized mols. were characterized by 1H NMR and 13C NMR spectroscopic anal. Compounds I [R = 3-pyridyl, 4-pyridyl] were found to be potentially active against gram neg. and gram-pos. bacteria with MIC value between 62.5 to 500μg/mL. The mol. docking studies of compounds I [R = Ph, 3-pyridyl] were further carried out to discover the interaction with active sites.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 2-Furoic hydrazide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Catalytic oxidation of benzyl-alcohol with H2O2 in the presence of a dioxidomolybdenum(VI) complex. Author is Balapoor, Leila; Bikas, Rahman; Dargahi, Maryam.

A new dioxidomolybdenum(VI) complex, [MoO2(L)(CH3OH)] (1), was synthesized by the reaction of MoO3 with ONO-donor hydrazone ligand that was obtained from the condensation of benzolyacetone and furan-2-carbohydrazide in methanol. Both of the ligand and complex were characterized by elemental anal. and FTIR, NMR and UV-visible spectroscopic methods. The structure of complex was also determined by single crystal x-ray anal. Structural anal. showed that the Mo(VI) ion has a distorted octahedral geometry and the ligand is coordinated to the metal ion as dineg. ONO-donor ligand. The obtained molybdenum(VI) complex was used as catalyst in oxidation of benzyl alc. with H2O2 as a green oxidant. The effects of some parameters such as temperature, solvent and ratio of materials were also studied. Catalytic studies indicated that complex 1 can efficiently catalyze the oxidation of benzyl alc. but its activity and selectivity are considerably dependent on the reaction condition.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Tin Powder-Promoted Cascade Condensation/Allylation/Lactamization: Synthesis of Isoindolinones and Pyrazoloisoindol-8-ones, published in 2019-06-07, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Category: benzisoxazole.

An efficient tin powder-promoted cascade condensation/allylation/lactamization of 2-formylbenzoic acids, hydrazides, and allyl bromides was developed for the synthesis of isoindolinones in good to excellent yields under mild conditions without any other additives or catalysts. Further manipulation of isoindolinones by iodocyclization process afforded the tricyclic tetrahydro-8H-pyrazolo[5,1-a]isoindol-8-one derivatives, which could be converted into more complicated tetracyclic tetrahydro-4H-azirino[1′,2′:2,3]pyrazolo[5,1-a]isoindol-4-ones.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37443-42-8, is researched, Molecular C6H10O3, about Preparation of γ-butyrolactones by the oxidation of monofunctional derivatives of tetrahydrofuran, the main research direction is furfuryl alc oxidation; furan alc ester oxidation; lactone aliphatic; butyrolactone acyloxy hydroxy.Quality Control of Methyl tetrahydrofuran-2-carboxylate.

Liquid phase oxidation of tetrahydrofurfuryl alc., its formate and acetate, and Me 2-tetrahydrofurancarboxylate, largely at 115°, in 10-25 hr in a flow-type glass reactor gave good yields of γ-butyrolactone or its γ-CH2OH, CH2O2CH, CH2OAc or CO2Me derivatives, resp., HCO2H and succinic acid. Evidently the oxidation occurred at the C2 and C5 positions. Uv light promoted the reaction and allowed its operation at lower temperature The summary yields of the lactones were 72-95%. The last substrate above was oxidized in the presence of Mn(OAc)2.4H2O catalyst at 70°.

In some applications, this compound(37443-42-8)Quality Control of Methyl tetrahydrofuran-2-carboxylate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of 2-Furoic hydrazide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Catalyst-free, aza-Michael polymerization of hydrazides: polymerizability, kinetics, and mechanistic origin of an α-effect. Author is Love, Dillon; Kim, Kangmin; Domaille, Dylan W.; Williams, Olivia; Stansbury, Jeffrey; Musgrave, Charles; Bowman, Christopher.

Despite the powerful nature of the aza-Michael reaction for generating C-N linkages and bioactive moieties, the bis-Michael addition of 1° amines remains ineffective for the synthesis of functional, step-growth polymers due to the drastic reduction in reactivity of the resulting 2° amine mono-addition adduct. In this study, a wide range of com. hydrazides are shown to effectively undergo the bis-Michael reaction with divinyl sulfone (DVS) and 1,6-hexanediol diacrylate (HDA) under catalyst-free, thermal conditions to afford moderate to high mol. weight polymers with Mn = 3.8-34.5 kg mol-1. The hydrazide-Michael reactions exhibit two distinctive, conversion-dependent kinetic regimes that are 2nd-order overall, in contrast to the 3rd-order nature of amines previously reported. The mono-addition rate constant was found to be 37-fold greater than that of the bis-addition at 80°C for the reaction between benzhydrazide and DVS. A significant majority (12 of 15) of the hydrazide derivatives used here show excellent bis-Michael reactivity and achieve >97% conversions after 5 days. This behavior is consistent with calculations that show minimal variance of electron d. on the N-nucleophile among the derivatives studied. Reactivity differences between hydrazides and hexylamine are also explored. Overall, the difference in reactivity between hydrazides and amines is attributed to the adjacent nitrogen atom in hydrazides that acts as an efficient hydrogen-bond donor that facilitates intramol. proton-transfer following the formation of the zwitterion intermediate. This effect not only activates the Michael acceptor but also coordinates with addnl. Michael acceptors to form an intermol. reactant complex.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics