Day: April 18, 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series, published in 2019-05-31, which mentions a compound: 3326-71-4, mainly applied to antiexudative antiinflammatory analgesic, Electric Literature of C5H6N2O2.

The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Cyclohexane-1,2-dicarboxylic acid(SMILESS: O=C([C@H]1[C@@H](C(O)=O)CCCC1)O,cas:610-09-3) is researched.Related Products of 39901-94-5. The article 《Reduction mechanism of cyclohexene-1,2-dicarboxylic acid》 in relation to this compound, is published in Denki Kagaku oyobi Kogyo Butsuri Kagaku. Let’s take a look at the latest research on this compound (cas:610-09-3).

Reduction mechanism of cyclohexene-1,2-dicarboxylic acid (I) was polarog. examined at pH 0-6. The first of the 3 waves that appeared was due to the adsorption of the product in strongly acid media. The 2nd wave was interpreted as due to a CEC (chem.-electrode-chem.) process involving preprotonation of the acid. The 3rd wave that appeared only in weakly acid media involved a CEC mechanism by which the free acid was reduced. The rate constant of the protonation of the monoanion from I was calculated Controlled-potential electrolysis produced a mixture of trans- and cis-cyclohexanedicarboxylic acid in high yield at pH 0-6. The stereoisomeric ratio of the products was influenced by pH; this was due to the difference of the stability of the reaction intermediates.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Cyclohexane-1,2-dicarboxylic acid(SMILESS: O=C([C@H]1[C@@H](C(O)=O)CCCC1)O,cas:610-09-3) is researched.HPLC of Formula: 652148-90-8. The article 《Photoreduction of carbon dioxide to its radical anion by nickel cluster [Ni3(μ3-I)2(dppm)3]: formation of two carbon-carbon bonds via addition of carbon dioxide radical anion to cyclohexene》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:610-09-3).

The trinuclear cluster Ni3(μ3-I)2(dppm)3, (1) [dppm = bis(diphenylphosphino)methane] is formed by conproportionation of Ni(COD)2 and NiI2 in the presence of dppm. Cluster 1 and its singly oxidized radical cation (2) have been characterized spectroscopically and by x-ray diffraction. Cluster 2 exhibits a slight Jahn-Teller distortion of its triangular nickel framework. Irradiation of 1 in the presence of CO2 results in photochem. electron transfer to produce CO2•- and 2. The CO2•- can be trapped by H-atom abstraction from toluene to produce formate ion or with cyclohexene to form cis- and trans-1,2-cyclohexanedicarboxylic acid. The radical anion disproportionation products, carbonate and CO, are observed in the absence of a trapping reagent for CO2•-.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Nguyen, D. Thao; Lenstra, Danny C.; Mecinovic, Jasmin published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).COA of Formula: C6H10O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

Unactivated carboxylic esters and primary amines undergo calcium-catalyzed direct amide bond formation to afford amides I [R1 = n-Pr, Ph, 4-hydroxybutyl, etc.; R2 = 2-thienyl, Ph, Bn, etc.] in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Category: benzisoxazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity.

Bacterial chemoreceptors mediate chemotactic responses to diverse stimuli. Here, by using an integrated in silico, in vitro, and in vivo approach, we screened a large compound library and found eight novel chemoeffectors for the Escherichia coli chemoreceptor Tar. Six of the eight new Tar binding compounds induce attractant responses, and two of them function as antagonists that can bind Tar without inducing downstream signaling. Comparison between the antagonist and attractant binding patterns suggests that the key interactions for chemotaxis signaling are mediated by the hydrogen bonds formed between a donor group in the attractant and the main-chain carbonyls (Y149 and/or Q152) on the α4 helix of Tar. This mol. insight for signaling is verified by converting an antagonist to an attractant when introducing an N-H group into the antagonist to restore the hydrogen bond. Similar signal triggering effect by an O-H group is also confirmed. Our study suggests that the Tar chemoeffector binding pocket may be separated into two functional regions: region I mainly contributes to binding and region II contributes to both binding and signaling. This scenario of binding and signaling suggests that Tar may be rationally designed to respond to a non-native ligand by altering key residues in region I to strengthen binding with the novel ligand while maintaining the key interactions in region II for signaling. Following this strategy, we have successfully redesigned Tar to respond to L-arginine, a basic amino acid that does not have chemotactic effect for WT Tar, by two site-specific mutations (R69’E and R73’E).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemoselective calcium-catalyzed direct amidation of carboxylic esters, published in 2015, which mentions a compound: 37443-42-8, mainly applied to amide green preparation chemoselective; carboxylic ester primary amine calcium catalyst amide bond formation, SDS of cas: 37443-42-8.

Unactivated carboxylic esters and primary amines undergo calcium-catalyzed direct amide bond formation to afford amides I [R1 = n-Pr, Ph, 4-hydroxybutyl, etc.; R2 = 2-thienyl, Ph, Bn, etc.] in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 37443-42-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions. Author is Rashed, Nurnobi Md.; Masuda, Koichiro; Ichitsuka, Tomohiro; Koumura, Nagatoshi; Sato, Kazuhiko; Kobayashi, Shu.

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines was developed in a continuous-flow system. A com. available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines required a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which rendered this process applicable for use in a sequential-flow system.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Photochemical transformations. XI. Isomerization of 1,3-cyclooctadiene》. Authors are Dauben, William G.; Cargill, Robert L..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Electric Literature of C8H12O4. Through the article, more information about this compound (cas:610-09-3) is conveyed.

cf. CA 54, 22718a. Com. 1,3-cyclooctadiene (I, n2D0 1.4940, λ 228 mμ (ε 5470, alc.), 22.1 g.) in 2 l. dry Et2O irradiated 200 hrs. with a Hanovia high pressure Hg arc lamp, internal probe, type L with magnetic stirring (He atm.), the progress of irradiation followed by ultraviolet spectroscopy to disappearance of I, the Et2O evaporated at 40-50° through a 1 ft. Vigreux column, and the yellow residue distilled through a Nester-Faust 2 ft. spinning band column gave 36-41% bicyclo[4.2.0]oct-7-ene (II), C8H12, b. 131-2°, n2D0 1.4720, λ205 mμ (ε 700, alc.), nuclear magnetic resonance singlets at 4.04 and complex multiplets at 7.21, 8.47 τ, infrared spectrum identical with that of material prepared from cyclooctatetraene dibromide. NaIO4 (9.78 millimoles), 0.16 millimole KMnO4, and 0.37 millimole K2CO3 in 200 ml. H2O stirred 25 hrs. at 25° with 1.03 millimoles II, the mixture acidified with 15% H2SO4, extracted 20 hrs. with Et2O, the dried extract evaporated, and the residue triturated with petr. ether gave 105 mg. solid, recrystallized from H2O and from Et2O-petr. ether to give cis-1,2-cyclohexanedicarboxylic acid, m. 197.5-8.0°. At no time was the typical spectrum of 1,3,5-hexatriene detected in the ultraviolet absorption spectrum of the irradiated solution

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Chalenko, N.; Demchenko, A.; Syrova, G. published the article 《Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series》. Keywords: antiexudative antiinflammatory analgesic.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Formula: C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).

In some applications, this compound(3326-71-4)Formula: C5H6N2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Product Details of 3326-71-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. Author is Abouzayed, Fatma I.; Emam, Sanaa M.; Abouel-Enein, Saeyda A..

Furo-(phenyldimethine)carbohydrazone (H2L) was prepared via the condensation reaction of 2-furoic acid hydrazide with terephthaldehyde by (2:1) molar ratio. Octahedral and square planar complexes were synthesized from the reaction of (H2L) ligand with chloride salts of Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) ions. All the chelates were structurally characterized by various anal. and spectral techniques. The stoichiometry of chelates was found to be 1:1, 1:2 and 1:3 (L:M) molar ratios to form sandwich, binuclear and trinuclear complexes, resp. All complexes were found to be non-electrolytic in nature on the basis of molar conductance values. The IR data showed that the ligand served as tetradentate in a neutral keto form. The ligand coordinated with all metal ions via oxygen atoms of carbonyl group and furan ring. The thermal properties of the ligand and its chelates were investigated utilizing thermogravimetry and reflected that Ru(III) complex has lower thermal stability than other complexes. X-ray diffraction spectra established nano-size for Ni(II) and Ru(III) complexes. The ESR result revealed axial symmetry with hyperfine structure for Cu(II) complex indicative of (2B1g) as a ground state. Some quantum parameters were reported in order to compare the reactivity of the compounds The biol. data indicated that all complexes have cytotoxic and antioxidant activity rather than the native ligand. Among all complexes, Ru(III) complex had excellent cytotoxic and antioxidant activity. This was due to its chem. structure and its nano-size.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics