Day: June 22, 2024

Vafadarnejad, Fahimeh et al. published their research in Letters in Drug Design & Discovery in 2017 | CAS: 334017-34-4

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. The presence of an amide bond, benzisoxazoles, chromans and fluorine atom substituents can alter the chemical properties, disposition, and biological activities of drugs. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.HPLC of Formula: 334017-34-4

Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity was written by Vafadarnejad, Fahimeh;Saeedi, Mina;Mahdavi, Mohammad;Rafinejad, Ali;Karimpour-Razkenari, Elahe;Sameem, Bilqees;Khanavi, Mahnaz;Akbarzadeh, Tahmineh. And the article was included in Letters in Drug Design & Discovery in 2017.HPLC of Formula: 334017-34-4 This article mentions the following:

Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different Et 5-arylisoxazole-3-carboxylate derivatives Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields. Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4HPLC of Formula: 334017-34-4).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. The presence of an amide bond, benzisoxazoles, chromans and fluorine atom substituents can alter the chemical properties, disposition, and biological activities of drugs. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.HPLC of Formula: 334017-34-4

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Cooper, Martin et al. published their research in Journal of Medicinal Chemistry in 2020 | CAS: 334017-34-4

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Many fluorinated compounds, 1,2-benzisoxazole derivatives and various amides are currently used in the treatment of diseases. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Formula: C10H6ClNO3

Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists was written by Cooper, Martin;Llinas, Antonio;Hansen, Peter;Caffrey, Moya;Ray, Asim;Sjoedin, Stina;Shamovsky, Igor;Wada, Hiroki;Jellesmark Jensen, Tina;Sivars, Ulf;Hultin, Leif;Andersson, Ulf;Lundqvist, Sara;Gedda, Karin;Jinton, Lisa;Krutroek, Nina;Lewis, Richard;Jansson, Paul;Gardelli, Cristina. And the article was included in Journal of Medicinal Chemistry in 2020.Formula: C10H6ClNO3 This article mentions the following:

Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease, and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of growth hormone secretion and subsequent increase of insulin-like growth factor-1 levels, an important mediator of muscle growth and repair. Ghrelin also acts on inflammation, appetite, and adipogenesis and therefore has been considered a promising therapeutic target for catabolic conditions. We previously reported on the synthesis and properties of an indane based series of ghrelin receptor full agonists which led to a sustained increase of insulin-like growth factor-1 in a dog pharmacodynamic study. Herein we report on the identification of a series of pyrrolidine or piperidine based full agonists and attempted optimization to give compounds with profiles suitable for progression as clin. candidates. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Formula: C10H6ClNO3).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Many fluorinated compounds, 1,2-benzisoxazole derivatives and various amides are currently used in the treatment of diseases. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Formula: C10H6ClNO3

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics