Month: July 2024

o-Iodoxy benzoic acid-mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids was written by Desai, Vidya G.;Naik, Sneha R.;Dhumaskar, Kashinath L.. And the article was included in Synthetic Communications in 2014.Category: benzisoxazole This article mentions the following:

A new, convenient, eco-friendly synthesis of 3,5-diarylisoxazoles is reported from α,β-unsaturated ketoximes. Similarly, a novel synthesis of isoxazolecarboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic 2-iodoxybenzoic acid (IBX) as an oxidative cyclization reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodol. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Category: benzisoxazole).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazole is an aromatic organic compound containing a benzene-fused isoxazole ring structure. It has reactive sites which allow for functionalization. The benzisoxazole scaffold and its analogues can be found in biologically active compounds across a number of different therapeutic areas as anti-HIV,antimicrobial, antipsychotic, anti-inflammatory, analgesic, and so on.Category: benzisoxazole

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

A modified method for the synthesis of 1,2-benzisoxazoles was written by Thakar, K. A.;Goswami, D. D.;Bhawal, B. M.. And the article was included in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 1977.Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole This article mentions the following:

Thirty-five substituted 1,2-benzisoxazoles (e.g. 3-methyl-, 3,5,7-trimethyl-6-chloro-3-ethyl-, etc.) were prepared in 85-100% yields by cyclizing o-hydroxyaryl ketoxime acetates in refluxing pyridine. Some of the benzisoxazoles exhibit antifungal activity (no data). In the experiment, the researchers used many compounds, for example, 7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole).

7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8) belongs to benzisoxazole derivatives. Many fluorinated compounds, 1,2-benzisoxazole derivatives and various amides are currently used in the treatment of diseases. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Design and synthesis of selective acetylcholinesterase inhibitors: Arylisoxazole-phenylpiperazine derivatives was written by Saeedi, Mina;Mohtadi-Haghighi, Dorrin;Mirfazli, Seyedeh Sara;Mahdavi, Mohammad;Hariri, Roshanak;Lotfian, Hania;Edraki, Najmeh;Iraji, Aida;Firuzi, Omidreza;Akbarzadeh, Tahmineh. And the article was included in Chemistry & Biodiversity in 2019.Product Details of 334017-34-4 This article mentions the following:

In this work, a novel series of arylisoxazole-phenylpiperazines were designed, synthesized, and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our results revealed that [5-(2-chlorophenyl)-1,2-oxazol-3-yl](4-phenylpiperazin-1-yl)methanone (5c) was the most potent AChE inhibitor with IC₅₀ of 21.85 μM. It should be noted that most of synthesized compounds showed no BChE inhibitory activity and [5-(2-fluorophenyl)-1,2-oxazol-3-yl](4-phenylpiperazin-1-yl)methanone (5a) was the most active anti-BChE derivative (IC₅₀=51.66 μM). Also, kinetic studies for the AChE and BChE inhibitory activity of compounds 5c and 5a confirmed that they have simultaneously bound to the catalytic site (CS) and peripheral anionic site (PAS) of both AChE and BChE. Furthermore, docking study of compound 5c showed desired interactions of that compound with amino acid residues located in the active and peripheral anionic sites. Compound 5c was also evaluated for its BACE1 inhibitory activity and demonstrated IC₅₀=76.78 μM. Finally, neuroprotectivity of compound 5c on Aβ-treated neurotoxicity in PC12 cells depicted low activity. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Product Details of 334017-34-4).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazole is an aromatic organic compound containing a benzene-fused isoxazole ring structure. Its aromaticity makes it relatively stable. Benzisoxazoles are found to display a variety of biological activities such as antiinflammatory, antioxidant, antidepressant, hypertensive, anticonvulsant, and anticoagulant properties.Product Details of 334017-34-4

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Discovery of novel 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole analogs as promising very long chain fatty acids inhibitors was written by Lin, Jian;Li, Yitao;Hu, Xiaoyun;Chi, Weilin;Zeng, Shuiming;Xu, Junxing. And the article was included in Journal of Heterocyclic Chemistry in 2021.Category: benzisoxazole This article mentions the following:

In order to explore and find novel VLCFAs inhibitors with higher herbicidal activity and improved crop safety, a variety of new I [R¹ = H, F; R² = H, F Cl, Br; R³ = H, F, Br] were reasonably designed and synthesized. The results of greenhouse experiments indicated that several compounds exhibited good herbicidal activity against Digitaria sanguinalis, Echinochloa crus-galli, and Setaria faberii at rates of 150 g ai/ha. Compounds I [R¹ = F, R² = R³ = H] and II [R¹ = R³ = H, R² = F] displayed promising herbicidal activity against D sanguinalis and E crus-galli at rates of 75 g ai/ha, which is better than com. pyroxasulfone and S-metolachlor. Moreover, compound II [R¹ = R³ = H, R² = F] displayed higher activity against E crus-galli, D sanguinalis, and S faberii than pyroxasulfone and S-metolachlor even at a rate of 37.5 and 18.75 g ai/ha. Furthermore, both of the compounds I [R¹ = F, R² = R³ = H] and II [R¹ = R³ = H, R² = F] were much safer to these tested crops, especially to rice, wheat and rape, at the rate of 150 g ai/ha than pyroxasulfone. Therefore, II [R¹ = R³ = H, R² = F] may act as a new lead structure for novel herbicides discovery. In the experiment, the researchers used many compounds, for example, 7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8Category: benzisoxazole).

7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8) belongs to benzisoxazole derivatives. Benzisoxazole is an aromatic organic compound containing a benzene-fused isoxazole ring structure. It has reactive sites which allow for functionalization. Functionalized benzisoxazoles and benzisoxazoyls have a variety of uses, including pharmaceutical drugs such as some antipsychotics and the anticonvulsant zonisamide.Category: benzisoxazole

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics