Month: August 2024

Saeedi, Mina et al. published their research in Letters in Drug Design & Discovery in 2021 | CAS: 334017-34-4

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. Recommanded Product: 334017-34-4

Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-thiadiazole Hybrids as α-Glucosidase Inhibitors was written by Saeedi, Mina;Eslami, Azadeh;Mirfazli, Seyedeh Sara;Zardkanlou, Mahsa;Faramarzi, Mohammad Ali;Mahdavi, Mohammad;Akbarzadeh, Tahmineh. And the article was included in Letters in Drug Design & Discovery in 2021.Recommanded Product: 334017-34-4 This article mentions the following:

Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids I (R = 2-Cl, 4-Me, 3,4-(OMe)2, etc.) possessing α- glucosidase inhibitory activity were developed. Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3- carboxylic acids II and Et 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evaluated for their α-glucosidase inhibitory activity. It was found that Et 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol- 2-yl)thio)acetate I (R = 2-Cl) was the most potent compound (IC50 = 180.1μM) compared with acarbose as the reference drug (IC50 = 750.0μM). Also, the kinetic study of I (R = 2-Cl) revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Good α-glucosidase inhibitory activity obtained by the title compounds I introduced them as an efficient scaffold, which has merits to be considered in anti-diabetic drug discovery developments. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Recommanded Product: 334017-34-4).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. Recommanded Product: 334017-34-4

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Saeedi, Mina et al. published their research in Polycyclic Aromatic Compounds in 2020 | CAS: 334017-34-4

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Recommanded Product: 334017-34-4

Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide was written by Saeedi, Mina;Hashemi, Mehdi;Mahdavi, Mohammad;Rafinejad, Ali;Najafi, Zahra;Mirfazli, Seyedeh Sara;Mohammadian, Razieh;Karimpour-Razkenari, Elahe;Kabudanian Ardestani, Sussan;Safavi, Maliheh;Akbarzadeh, Tahmineh. And the article was included in Polycyclic Aromatic Compounds in 2020.Recommanded Product: 334017-34-4 This article mentions the following:

In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Recommanded Product: 334017-34-4).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Recommanded Product: 334017-34-4

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics