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Synthesis of a new series of urea/thiourea derivatives of Gly/Pro conjugated benzisoxazole has been reported. Structure of the compounds was characterized by physical and spectroscopical data and has been screened for their in vitro antiglycation activity. Several compounds showed promising activity with IC50 <5 mu M compared to standard rutin (IC50 = 41.9 mu M). Further, it was found that compounds containing methoxy and bromine substituents have exerted highly potent activity. Thus, the title compounds represent novel class of potent antiglycating agents. (C) 2012 Elsevier Masson SAS. All rights reserved. Safety of Sodium pyruvate, In the meantime we’ve collected together some recent articles in this area about 113-24-6 to whet your appetite. Happy reading!
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics