Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 52356-01-1, Name is 2-Hydrazinobenzoic acid hydrochloride, SMILES is O=C(O)C1=CC=CC=C1NN.[H]Cl, in an article , author is Fukuda, Takeshi, once mentioned of 52356-01-1, Application In Synthesis of 2-Hydrazinobenzoic acid hydrochloride.
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (D879182026), which showed serum hepcidin lowering effects in a mouse 1L-6 induced acute inflammatory model. (C) 2017 Elsevier Ltd. All rights reserved.
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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics