As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. “.
O-ARYLKETOXIMES .3. OBTAINING 3-(4′-METHYL)-PHENYL-5-NITRO-BENZISOXAZOLE FROM O-[2-(4′-METHYL)-BENZOYL-4-NITRO]-PHENYL-KETOXIMES
Refluxing O-[2-(4′-methyl)-benzoyl-4-nitro]-phenyl-ketoximes (3) in ethanol saturated with hydrocloric acid, besides ketones 5,3-(4′-methyl)-phenyl-5-nitro-benzisoxazole 4 was obtained instead of the corresponding benzofurans 6. The formation of 4 is possible by spliting the oximic bond of 3 into O-[2-(4’methyl)-benzoyl-4-nitro]-phenylhydroxylamine 8 and ketones 5, under acid catalysis. Further on, the arylhydroxylamine 8 turns into 4 by cyclization, a new intramolecular oximic bound being formed.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4246-51-9, you can contact me at any time and look forward to more communication. Electric Literature of 4246-51-9.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics