Chemical Research Letters, May 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is Vijayakumar, E. K. S., once mentioned the application of 15026-17-2, Name is 4-(tert-Butoxy)-4-oxobutanoic acid, molecular formula is C8H14O4, molecular weight is 174.19, MDL number is MFCD00273441, category is benzisoxazole. Now introduce a scientific discovery about this category, Recommanded Product: 4-(tert-Butoxy)-4-oxobutanoic acid.
HPLC method for simultaneous determination of impurities and degradation products in zonisamide
A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150FNx013.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (75:10:15 v/v/v), pH adjusted to 4.0 with orthophosphoric acid. The mobile phase component B consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (15:40:45 v/v/v), pH 2.0 with orthophosphoric acid. The limit of detection and limit of quantitation were in the range of 0.001-0.007 and 0.0035-0.25 respectively with respect to sample concentration of 2 mg/ml. The method was linear in the range of LOQ level to 200 of specified limits for II-VIII (< 0.10, r (2) = 0.9958-0.9999). The method is sensitive, specific, linear, accurate, precise and stability-indicating for the detection and quantitation of precursors (viz., 4-hydroxycoumarin, 1,2-benzisoxazole-3-acetic acid, 1,2-benzisoxazole-3-bromoacetic acid, 1,2-benzisoxazole-3-methylbromide, sodium 1,2-benzisoxazole-3-methanesulfonate), process impurities (viz., 2-hydroxyacetophenone oxime and 3,3,3-tribromomethyl-1,2-benzisoxazole) and drug degradation products formed under stress conditions. If you are interested in 15026-17-2, you can contact me at any time and look forward to more communication. Recommanded Product: 4-(tert-Butoxy)-4-oxobutanoic acid.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics