New Advances in Chemical Research in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 526-83-0, Name is 2,3-Dihydroxysuccinic acid, molecular formula is C4H6O6, Quality Control of 2,3-Dihydroxysuccinic acid, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Rajendraprasad, Nagaraju, once mentioned the new application about 526-83-0.
EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF QUETIAPINE FUMARATE IN PHARMACEUTICALS AND HUMAN URINE USING CALMAGITE AS AN ION-PAIR REAGENT
Quetiapine fumarate (QTF) is an antipsychotic drug belonging to the benzisoxazole derivatives indicated for the treatment of schizophrenia. A sensitive and selective method based on dichloromethane-extractable ion-pair of QTF with calmagite (CGT), which exhibited an absorption maximum at 490 nm, is described. At this. wavelength, Beer’s law is obeyed over the concentration range of 3.0-30.0 mu g ml(1). The apparent molar absorptivity, limit of detection (L OD) and quantitation (LOQ) values are 1.32×10(4) I mol(1) cm(-1), 0.27 and 0.81 mu g ml(1), respectively. The reaction is extremely rapid at room temperature and the absorbance values remain unchanged up to 19 h. The precision results, expressed as intra-day and inter-day relative standard deviation values, are satisfactory (RSD <= 2.2%). The accuracy is satisfactory as well (RE <= 2.44%). The method was successfully applied to the determination of QTF in pharmaceuticals and spiked human urine with satisfactory results. No interference was observed from common pharmaceutical adjuvants in tablets. Statistical comparison of the results with the official method showed an excellent agreement and indicated no significant difference in precision. Quality Control of 2,3-Dihydroxysuccinic acid, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 526-83-0.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics