Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 532-32-1, Name is Sodium benzoate, SMILES is O=C([O-])C1=CC=CC=C1.[Na+], in an article , author is Gopalsamy, Ariamala, once mentioned of 532-32-1, Electric Literature of 532-32-1.
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90
Heat shock protein 90 (Hsp90) is a molecular chaperone that is responsible for activating many signaling proteins and is a promising target in tumor biology. We have identified small-molecule benzisoxazole derivatives as Hsp90 inhibitors. Crystallographic studies show that these compounds bind in the ATP binding pocket interacting with the Asp93. Structure based optimization led to the identification of potent analogues, such as 13, with good biochemical profiles.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics