Synthetic Route of 4865-84-3, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way.4865-84-3, Name is 1,2-Benzisoxazole-3-acetic Acid, molecular formula is C9H7NO3. In a Article£¬once mentioned of 4865-84-3
1,2-Benzisoxazole-3-acetamide derivatives as dual agents for DPP-IV inhibition and anticancer activity
Herein, we have designed various benzisoxazole acetamide derivatives with and without glycine spacer as DPP-IV inhibitors. Compounds 9a?d and 11a?e were synthesized and screened for their in vitro DPP-IV inhibition. Compounds 11a and 11c showed moderate activity for DPP-IV inhibition, whereas other remained inactive at 25?200 muM concentrations. DPP-IV inhibition can be a good strategy for modulating diabetes and cancer; hence, we have screened compounds 9a?d and 11a?e for their anticancer activity using MTT assay against A549 and MCF7 cell lines. Compounds 9a?d without glycine spacer have shown good anticancer activity compared to compounds 11a?e with glycine spacer. Compound 9b has shown moderate activity with IC50 values 4.72 ¡À 0.72 and 4.39 ¡À 0.809 muM against A549 and MCF7 cell lines, respectively. Interestingly, compound 9c with cyano group has shown very good anticancer activity with IC50 2.36 ¡À 0.34 muM against MCF7 cell line as compared to fluorouracil with IC50 45.04 ¡À 1.02 muM.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4865-84-3 is helpful to your research. Synthetic Route of 4865-84-3
Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics