37924-85-9, 3-(Bromomethyl)benzo[d]isoxazole is a Benzisoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-Bromomethyl-benzo[d]isoxazole-5-sulfonyl chloride Chlorosulfonic acid (1.5 ml, 22 mmol) was slowly added to 3-Bromomethyl-benzo[d]isoxazole (1.0 g, 4.7 mmol) at RT under argon. The reaction was heated at 90 C. for 12 h and then left at RT for 6 h. The resulting viscous oil was quenched over ice, extracted with EtOAc, dried over MgSO4 and concentrated in vacuo to a brown oil (1.17 g, 80% yield).; 3-Bromomethyl-benzo[d]isoxazole-5-sulfonyl chloride Chlorosulfonic acid (1.5 ml, 22 mmol) was slowly added to 3-Bromomethyl-benzo[d]isoxazole (1.0 g, 4.7 mmol) at RT under argon. The reaction was heated at 90 C. for 12 h and then left at RT for 6 h. The resulting viscous oil was quenched over ice, extracted with EtOAc, dried over MgSO4 and concentrated in vacuo to a brown oil (1.17 g, 80% yield). After reaction of this material with the core the aliphatic bromine may be displaced by an appropriate nucleophile.
The synthetic route of 37924-85-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sequoia Pharmaceuticals; US2005/267074; (2005); A1;,
Benzisoxazole – Wikipedia
Benzisoxazole – an overview | ScienceDirect Topics