Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Category: Benzisoxazole, 40052-13-9, Name is 3-Tert-butoxy-3-oxopropanoic acid, molecular formula is C7H12O4, belongs to Benzisoxazole compound. In a document, author is Bhaskarachar, Ravi Kiran, introduce the new discover.
Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids
A new series of spiro-quinoline compounds have been accomplished by the reaction of barbituric acid or thiobarbituric acid with derivatives of benzisoxazole-5-carbaldehyde or 2-substituted benzaldehyde. These compounds were evaluated for their in vitro cytotoxicity on two mammalian cancer cell lines MCF-7 and KB. The compounds exhibit cytotoxicity against these cell lines in micromolar range. Among the series of compounds, 11(a-j) particularly 11b and 11e showed relatively good activity against both the tested cell lines. Compound 11b was found to exhibit the highest cytotoxic activity with IC50 value 90.2 mu M for MCF-7 and 49.8 mu M for KB cell line. Flow cytometric analysis study confirmed that these molecules induced cytotoxicity via apoptosis.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 40052-13-9. Category: Benzisoxazole.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics