Chemistry is an experimental science, Category: Benzisoxazole, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 113-24-6, Name is Sodium pyruvate, molecular formula is C3H3NaO3, belongs to Benzisoxazole compound. In a document, author is Solanki, Pavankumar V..
Improved and Efficient Process for the Production of Highly Pure Iloperidone: A Psychotropic Agent
The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone (4) with 6-fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of tetrabutylammonium bromide as a phase transfer catalyst to yield iloperidone (1) with a yield of around 95% and a purity of 99.80% by HPLC. The present work also describes the optimization details performed to achieve the process attributes responsible for high yield and purity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 113-24-6, in my other articles. Category: Benzisoxazole.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics