Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hoy, Sheridan M., once mentioned the application of 99-06-9, Name is 3-Hydroxybenzoic acid, molecular formula is C7H6O3, molecular weight is 138.12, MDL number is MFCD00002506, category is Benzisoxazole. Now introduce a scientific discovery about this category, Product Details of 99-06-9.
Zonisamide: A Review of Its Use as Adjunctive Therapy in the Management of Partial Seizures in Pediatric Patients Aged >= 6 Years
Oral zonisamide (Zonegran(A (R))) is a benzisoxazole derivative chemically unrelated to other antiepileptic drugs (AEDs). It is approved in the EU as an adjunct to other AEDs in the treatment of pediatric patients aged a parts per thousand yen6 years with partial seizures, with or without secondary generalization. In a randomized, double-blind, multinational, phase III study in pediatric patients aged 6-17 years with partial seizures, the proportion of patients achieving a a parts per thousand yen50 % reduction from baseline in seizure frequency per 28 days during the maintenance treatment period was significantly higher with adjunctive therapy with zonisamide than placebo. The antiepileptic efficacy of zonisamide was sustained during a 59-week extension study in this patient population. Zonisamide was generally well tolerated in these studies, with the majority of adverse events being mild or moderate in severity. Thus, oral zonisamide as an adjunctive therapy to other AEDs provides a useful option in the treatment of pediatric patients aged a parts per thousand yen6 years with partial seizures.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics