Synthetic Route of 75-98-9, New Advances in Chemical Research, May 2021.Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur, causing turnover rates to depend strongly on interfacial structure and composition. 75-98-9, Name is Pivalic acid, SMILES is CC(C)(C)C(O)=O, belongs to benzisoxazole compound. In a article, author is Seino, M, introduce new discover of the category.
Zonisamide is a benzisoxazole-based compound first synthesized in the early 1970s by the research laboratories of Dainippon Pharmaceutical Company in Osaka, Japan. Identified as an anticonvulsant during exploratory research, zonisamide has since been characterized as having broad-spectrum antiepitepsy and neuroprotective effects. Early clinical studies in Japan demonstrated that zonisamide has a long elimination half-life and is well tolerated; Phase II and III clinical trials established the drug’s efficacy and safety for the treatment of partial and generalized seizures. In 1989, zonisamide was approved and marketed in Japan under the trade name of Excegran(R). Data from postmarketing surveillance studies and clinical observations over 10 years of use have continued to support zonisamide’s efficacy and safety, identified its usefulness as monotherapy, and characterized its effectiveness for various seizure types and epilepsy syndromes. (C) 2004 Published by Elsevier Ltd on behalf of BEA Trading Ltd.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics