While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards.113-24-6, Name is Sodium pyruvate, SMILES is O=C(C)C([O-])=O.[Na+], in an article , author is Lee, Lljung, once mentioned of 113-24-6, Related Products of 113-24-6.
Objectives Alzheimer’s disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the postmortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenyimethyl)-4piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radiolodine and evaluated as an AChE imaging agent for SPECT. Methods Radioiodine-labelled CP-118,954 was prepared from CP-144,885 and [I-125]iodobenzyl bromide, and anti-AChE activities of iodine-substituted CP-118,954 were measured. Metabolism studies were carried out in samples of blood and whole brain of mice injected with 2[I-123]iodo-CP-118,954 (I-123-1). Tissue distribution studies were also performed in mice injected with I-125-1, and samples of blood, thyroid, stomach, and brain tissue (cerebellum, striatum and cortex) were removed, weighed and counted. Results Of the ligands, 2-iodo-CP-118,954 exhibited higher binding affinity for AChE (IC50 = 24 nM) than the other positional isomers. 2-[I-125]lodo-CP-118,954 was found to have a lipophilicity (log P=2.1) favouring brain permeability and metabolic stability in mouse brain, but a marginal target (striatum) to non-target (cerebellum) uptake ratio (1.1) in mouse brain. Conclusion This result demonstrates that 2-[I-125]iodo-CP-118,954 may be unsuitable for AChE imaging. These findings suggest that radioligands suitable for AChE imaging should have not only a specific structure but also a sub-nanomolar to low nanomolar IC50.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 113-24-6. Related Products of 113-24-6.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics