The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A novel turn on fluorescent probe for the determination of Al3+ and Zn2+ ions and its cells applications, the main research direction is fluorescent probe aluminum zinc cell imaging; Aluminum and Zinc ion; Fluorescence sensor.Synthetic Route of C5H6N2O2.
Early detection of probes is very important for limiting toxic effects of various transition metal ions for example aluminum and zinc. Monitoring of these metal ions can be challenging via conventional methods since they are high cost instrumentations, time consuming and so on. The authors report facile preparation of a fluorescence probe containing biphenyl groups that effectively selective and superb sensitivity towards aluminum(III) and zinc(II) in neutral solutions without interference from each other and other ions. In neutral pH value, the probe FOB displayed the OFF-ON fluorescence enhancement at 464 nm and 512 nm toward aluminum(III) and zinc(II), resp. The detection limit values of FOB for Al3+ and Zn2+ in neutral solutions were 1.27 and 1.02 nM, resp. and these values were significantly lower than permitted Al3+ and Zn2+ concentrations in drinking water determined by the World Health Organization (WHO) and European Water Quality. Also, fabricated cyano-biphenyl based probe is effective for sensing for aluminum(III) and zinc(II) in living human colon cancer cells even when employed at low concentrations (1.0μM). Overall, this work allows the authors to obtain a great potential to be applied to detect Al3+ and Zn2+.
As far as I know, this compound(3326-71-4)Synthetic Route of C5H6N2O2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics