So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nakagawa, Atsushi; Kato, Ko; Shinmyo, Atsuhiko; Suzuki, Toshio researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).COA of Formula: C6H10O3.They published the article 《Asymmetric hydrolysis of 2-hydroxy-carboxylic esters using recombinant Escherichia coli》 about this compound( cas:37443-42-8 ) in Tetrahedron: Asymmetry. Keywords: whole cell kinetic resolution ester stereoselective. We’ll tell you more about this compound (cas:37443-42-8).
Optically active 2-hydroxy-carboxylates are important compounds for their use as intermediates in the synthesis of pharmaceuticals and stereoblock polymers. Enterobacter sp. DS-S-75 and the recombinant Escherichia coli harboring the 4-chloro-3-hydroxybutyrate (CHB) hydrolase gene from the strain DS-S-75 showed asym. hydrolytic activity towards 2-hydroxy-carboxylates, as well as towards CHB. It was discussed that the hydroxyl group in the substrate was particularly important for the asym. hydrolytic activity of the CHB hydrolase, and as such, it was re-designated to EnHCH (hydroxy-carboxylic ester hydrolase derived from Enterobacter sp.). Using the recombinant cell, both the reaction rate and the concentration of the substrates were significantly improved upon when compared to that of DS-S-75. Optically active 2-hydroxy-carboxylates could be synthesized on a practical basis for industrial production in this report.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics