So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mendes da Silva, Joaquim Fernando; Walters, Marcus; Al-Damluji, Saad; Ganellin, C. Robin researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Application of 37443-42-8.They published the article 《Molecular features of the prazosin molecule required for activation of Transport-P》 about this compound( cas:37443-42-8 ) in Bioorganic & Medicinal Chemistry. Keywords: prazosin analog preparation activation Transport P amine. We’ll tell you more about this compound (cas:37443-42-8).
Closely related structural analogs of prazosin have been synthesized and tested for inhibition and activation of Transport-P in order to identify the structural features of the prazosin mol. that appear to be necessary for activation of Transport-P. So far, all the compounds tested are less active than prazosin. It is shown that the structure of prazosin appears to be very specific for the activation. Only quinazolines have been found to activate, and the presence of the 6,7-dimethoxy and 4-amino groups appears to be critically important.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics