651780-27-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Ethyl 6-bromobenzo[d]isoxazole-3-carboxylate, cas is 651780-27-7,the Benzisoxazole compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of ethyl 6-bromobenzisoxazole-3-carboxylate (2.0 g, 7.4 mmol) and t- butyl 5-cyanoanthranilate (1.62 g, 7.4 mmol) in toluene (27 [ML)] is added NaH (1.5 g of a 60% mineral oil dispersion, 3.8 mmol) under N2. The reaction mixture is stirred overnight at rt. This mixture is diluted with aq 1 N [HCI,] extracted with EtOAc (0.2 L). The EtOAc solution is dried and concentrated to give Preparation Pb as a solid : 1H NMR (300 MHz, CDC13) [8] 12.8 (1H), 9.05 [(1H),] 8.38 (1H), 8.18 (1H), 7.92 (1H), 7.82 (1H), 7.61 [(1H),] [1.] 69 [(9H).]
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 6-bromobenzo[d]isoxazole-3-carboxylate, 651780-27-7
Reference£º
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/18428; (2004); A1;,
Benzisoxazole – Wikipedia
Benzisoxazole – an overview | ScienceDirect Topics