Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, New Journal of Chemistry called On the importance of antiparallel π-π interactions in the solid state of isatin-based hydrazides, Author is Ahmed, Muhammad Naeem; Arif, Maryam; Jabeen, Farah; Khan, Haroon Ahmed; Yasin, Khawaja Ansar; Tahir, Muhammad Nawaz; Franconetti, Antonio; Frontera, Antonio, which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Quality Control of 2-Furoic hydrazide.
The condensation of N-Pr isatin (1) with different carboxylic acid hydrazides (RCONHNH2 (2-6), R = arene) via sonication was used to synthesize five new hydrazones (7-11). Fully characterized mol. structures were further studied by single-crystal X-ray diffraction showing them to be Z-(syn-) form with respect to the hydrazoic C=N bond. In the crystal structures, hydrogen bonds and π-stacking interactions are described and analyzed by means of d. functional theory (DFT) calculations since they play a crucial role in the construction of three-dimensional supramol. frameworks. Moreover, the noncovalent interactions have been characterized using the NCIplot index. Remarkably, the π-system of the substituted isatin ring presents a dual character (acidic/basic), thus promoting the formation of the antiparallel π-stacking assemblies to maximize electron donor-acceptor π-π interactions. Moreover, interesting cooperativity effects have been studied since the presence of an intramol. H-bonding interaction enhances the strength of the π-π interactions as shown by DFT calculations
After consulting a lot of data, we found that this compound(3326-71-4)Quality Control of 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics