Rojas, Juan J.; Croft, Rosemary A.; Sterling, Alistair J.; Briggs, Edward L.; Antermite, Daniele; Schmitt, Daniel C.; Blagojevic, Luka; Haycock, Peter; White, Andrew J. P.; Duarte, Fernanda; Choi, Chulho; Mousseau, James J.; Bull, James A. published the artcile< Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides>, Safety of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is sulfonyl fluoride amine defluorosulfonylative coupling; amino oxetane chemoselective preparation.
A class of reactions for sulfonyl fluorides to form amino-oxetanes by an alternative pathway to the established SuFEx (sulfonyl-fluoride exchange) click reactivity. A defluorosulfonylation forms planar oxetane carbocations simply on warming. This disconnection, comparable to a typical amidation, will allow the application of vast existing amine libraries. The reaction was tolerant to a wide range of polar functionalities and was suitable for array formats. Ten oxetane analogs of bioactive benzamides and marketed drugs were prepared Kinetic and computational studied support the formation of an oxetane carbocation as the rate-determining step, followed by a chemoselective nucleophile coupling step.
Nature Chemistry published new progress about Activation energy. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Safety of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics