Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity was written by Vafadarnejad, Fahimeh;Saeedi, Mina;Mahdavi, Mohammad;Rafinejad, Ali;Karimpour-Razkenari, Elahe;Sameem, Bilqees;Khanavi, Mahnaz;Akbarzadeh, Tahmineh. And the article was included in Letters in Drug Design & Discovery in 2017.HPLC of Formula: 334017-34-4 This article mentions the following:
Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different Et 5-arylisoxazole-3-carboxylate derivatives Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields. Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4HPLC of Formula: 334017-34-4).
5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. The presence of an amide bond, benzisoxazoles, chromans and fluorine atom substituents can alter the chemical properties, disposition, and biological activities of drugs. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.HPLC of Formula: 334017-34-4
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics