719-64-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Chloro-3-phenylbenzo[c]isoxazole, cas is 719-64-2,the Benzisoxazole compound, it is a common compound, a new synthetic route is introduced below.
That is, using the above conditions, Aldimine 1a (54.7mg, 0.2mmol, 100mol%),[RhCp * Cl2] 2 (3.1mg, 0.005mmol, 2.5mol%), AgSbF6 (6.9mg, 0.02mmol, 10mol%),Then in an oven dried and sealed tube filled with PivOH (10.2mg, 0.1mmol, 50mol%),Under room temperature and air, anthranyl 2a (68.9 mg, 0.3 mmol, 200 mol%) and DMF (1 mL) were added.The reaction mixture was stirred at 120 C. for 6 hours and cooled to room temperature.The reaction mixture was diluted with EtOAc (3 mL) and concentrated in vacuo.The residue was purified by flash column chromatography (n-hexane / EtOAc = 7: 1) to give 3a (48.2 mg) in 73% yield.
The chemical industry reduces the impact on the environment during synthesis,719-64-2,5-Chloro-3-phenylbenzo[c]isoxazole,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; SUNGKYUNKWAN University Research & Business Foundation; Kim In-su; Kim Hyeong-sik; (41 pag.)KR2020/25255; (2020); A;,
Benzisoxazole – Wikipedia
Benzisoxazole – an overview | ScienceDirect Topics