In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities, published in 2021, which mentions a compound: 3326-71-4, mainly applied to diethylaminocoumarinyl oxadiazole preparation acetylcholinesterase inhibition SAR docking; 1,3,4-oxadiazole; Coumarin; acetylcholinesterase inhibitor; molecular docking, Safety of 2-Furoic hydrazide.
Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives I [R = n-Bu, 2-thienyl, Ph, etc.] were synthesized via iodine-mediated oxidative cyclization and confirmed by 1H NMR, 13C NMR and HRMS. The synthesized derivatives I were tested against in-vitro acetylcholinesterase inhibitory activity and results showed that compounds I [R = 4-ClC6H4, 4-BrC6H4] exhibited moderate inhibitory activities with 69.19% and 65.06%, resp. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of Ph of compounds I could enhance their activities. Mol. docking study suggested that compound I [R = ClC6H4] possessed an optimal docking pose with interactions inside AChE.
If you want to learn more about this compound(2-Furoic hydrazide)Safety of 2-Furoic hydrazide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3326-71-4).
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics