Rani Gupta, Shraddha; Yadav, Pranjalee; Singh, Priya; Koch, Biplob; Singh, Vinod P. published the article 《A “”Turn-On”” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies》. Keywords: lung cancer aluminum water soluble fluorescent probe furan.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Safety of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.
A furan-based water soluble fluorescent probe (E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1H NMR, 13C NMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “”turn-on”” fluorescence response towards Al3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo-induced electron transfer) and C=N isomerization. 1 : 1 stoichiometric ratio between DBF and Al3+ was rationalized by Job′s plot. Binding constant and LOD were calculated to be 1.031×105 M-1 and 6.34×10-8 M, resp. MTT assay on live A549 cells indicated no serious cytotoxicity in the cells even at higher concentration Further, DBF was successfully used for the detection of accumulated Al3+ in the cytoplasm of cells.
There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Safety of 2-Furoic hydrazide, and with the development of science, more effects of this compound(3326-71-4) can be discovered.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics