Chemistry, like all the natural sciences, COA of Formula: C10H12O2, begins with the direct observation of nature¡ª in this case, of matter.536-66-3, Name is 4-Isopropylbenzoic acid, SMILES is C1=CC(=CC=C1C(C)C)C(O)=O, belongs to Benzisoxazole compound. In a document, author is Vanjari, Rajeshwer, introduce the new discover.
Ring Expansion and 1,2-Migration Cascade of Benzisoxazoles with Ynamides: Experimental and Theoretical Studies
Demonstrated herein is an Au-I-catalyzed annulation of sulfonyl-protected ynamides with substituted 1,2-benzisoxazoles for the synthesis of E-benzo[e][1,3]oxazine derivatives. The transformation involves the addition of benzisoxazole to the gold-activated ynamide, ring expansion of the benzisoxazole fragment to provide an alpha-imino vinylic gold intermediate, and 1,2-migration of the sulfonamide motif to the masked carbene center to deliver the respective ring-expanded benzo[e][1,3]oxazine of predominant E configuration. A trapping experiment justifies the participation of the alpha-imino masked gold carbene. DFT computations also support the hypothesized mechanism and rationalize the product stereoselectivity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 536-66-3. COA of Formula: C10H12O2.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics