99-14-9, Name is Propane-1,2,3-tricarboxylic acid, molecular formula is C6H8O6, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Butzbach, Danielle M., once mentioned the new application about 99-14-9, Safety of Propane-1,2,3-tricarboxylic acid.
Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood
The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high-performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37 degrees C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7 degrees C, but degraded significantly in inoculated blood at 20 and 37 degrees C. Complete loss occurred within 2 days when incubated at 37 degrees C. The benzisoxazole-cleaved degradation products for both drugs were identified as 2-hydroxybenzoyl-risperidone and 2-hydroxybenzoyl-paliperidone utilizing liquid chromatography quadrupole-time-of-flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 99-14-9. The above is the message from the blog manager. Safety of Propane-1,2,3-tricarboxylic acid.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics