Research speed reading in 2021. Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 557-59-5, Name is Tetracosanoic acid, SMILES is CCCCCCCCCCCCCCCCCCCCCCCC(O)=O, in an article , author is Lee, Lljung, once mentioned of 557-59-5, Application In Synthesis of Tetracosanoic acid.
Objectives Alzheimer’s disease (AD) is characterized by reduced acetylcholinesterase (AChE) activity in the postmortem tissues of AD patients. Therefore, AChE has been an attractive target for the diagnosis of AD. In the present study, 5,7-dihydro-3-[2-(1-(phenyimethyl)-4piperidinyl)ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one (CP-118,954), a potent AChE inhibitor, was labelled with radiolodine and evaluated as an AChE imaging agent for SPECT. Methods Radioiodine-labelled CP-118,954 was prepared from CP-144,885 and [I-125]iodobenzyl bromide, and anti-AChE activities of iodine-substituted CP-118,954 were measured. Metabolism studies were carried out in samples of blood and whole brain of mice injected with 2[I-123]iodo-CP-118,954 (I-123-1). Tissue distribution studies were also performed in mice injected with I-125-1, and samples of blood, thyroid, stomach, and brain tissue (cerebellum, striatum and cortex) were removed, weighed and counted. Results Of the ligands, 2-iodo-CP-118,954 exhibited higher binding affinity for AChE (IC50 = 24 nM) than the other positional isomers. 2-[I-125]lodo-CP-118,954 was found to have a lipophilicity (log P=2.1) favouring brain permeability and metabolic stability in mouse brain, but a marginal target (striatum) to non-target (cerebellum) uptake ratio (1.1) in mouse brain. Conclusion This result demonstrates that 2-[I-125]iodo-CP-118,954 may be unsuitable for AChE imaging. These findings suggest that radioligands suitable for AChE imaging should have not only a specific structure but also a sub-nanomolar to low nanomolar IC50.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 557-59-5. Application In Synthesis of Tetracosanoic acid.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics