In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A, published in 2021, which mentions a compound: 442903-28-8, Name is Methyl 2,4-dichloronicotinate, Molecular C7H5Cl2NO2, HPLC of Formula: 442903-28-8.
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step.
This literature about this compound(442903-28-8)HPLC of Formula: 442903-28-8has given us a lot of inspiration, and I hope that the research on this compound(Methyl 2,4-dichloronicotinate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics