Stevanovic, Strahinja; Sencanski, Milan; Danel, Mathieu; Menendez, Christophe; Belguedj, Roumaissa; Bouraiou, Abdelmalek; Nikolic, Katarina; Cojean, Sandrine; Loiseau, Philippe M.; Glisic, Sanja; Baltas, Michel; Garcia-Sosa, Alfonso T. published the article 《Synthesis, in silico, and in vitro evaluation of anti-leishmanial activity of oxadiazoles and indolizine containing compounds flagged against anti-targets》. Keywords: Leishmania leishmaniasis antileishmanial oxadiazole indolizine MSBAR; Leishmania; anti-leishmanial inhibitors; anti-target; arginase; in silico; in vitro.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Application In Synthesis of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.
Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential. This study describes the synthesis of a series of novel oxadiazoles and indolizine-containing compounds The compounds were screened in silico using an EIIP/AQVN filter followed by ligand-based virtual screening and mol. docking to parasite arginase. Top hits were further screened vs. human arginase and finally against an anti-target battery to tag their possible interactions with proteins essential for the metabolism and clearance of many substances. Eight candidate compounds were selected for further exptl. testing. The results show measurable in vitro anti-leishmanial activity for three compounds One compound with an IC50 value of 2.18 μM on Leishmania donovani intramacrophage amastigotes is clearly better positioned than the others as an interesting mol. template for further development of new anti-leishmanial agents.
In some applications, this compound(3326-71-4)Application In Synthesis of 2-Furoic hydrazide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics