The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 2,4-dichloronicotinate(SMILESS: ClC1=C(C(=O)OC)C(=CC=N1)Cl,cas:442903-28-8) is researched.Name: Ir(p-CF3-ppy)3. The article 《Palladium-Catalyzed Site-Selective Amidation of Dichloroazines》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:442903-28-8).
A highly site-selective amidation reaction of substituted 2,4-dichloroazines is reported. Palladium acetate/1,1′-bis(diphenylphosphino)ferrocene (dppf) was identified as the optimal catalyst system, producing >99:1 C-2/C-4 selectivity for most examples. The generality of this transformation was demonstrated through a survey of a diverse amide/substituted 2,4-dichloroazine scope, leading to the preparation of the desired C-2 amidated products in good to excellent yields.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics