The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, antimicrobial and antioxidant evaluation, and molecular docking study of 4,5-disubstituted 1,2,4-triazole-3-thiones, the main research direction is triazole thione preparation docking antibacterial antifungal antioxidant activity.Name: 2-Furoic hydrazide.
In order to develop potential antimicrobial agents, some 1,2,4-triazole-3-thiones I (R = Et, Ph, 4-nitrophenyl, etc.; Ar = Ph, furan-2-yl, pyridin-4-yl, etc.) were synthesized from the reaction of hydrazides ArC(O)NHNH2 with isothiocyanates RN=C=S under optimized conditions in deep eutectic solvent of potassium carbonate-glycerol (1:5 M ratio). Blocking properties of all products were assessed on a variety of Gram-pos. and Gram-neg. bacterial as well as fungal pathogens. Good to excellent inhibitory effects especially against fungi were observed with all synthesized compounds Compound I (R = 4-nitrophenyl; Ar = 4-hydroxyphenyl) showed significant antioxidant activity according to the results obtained from 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging experiments The possible interaction mechanism of synthetic triazoles with 1IYL enzyme on Aspergillus fumigatus was investigated by mol. docking method. A complete agreement was found between exptl. data and theor. calculations Hydrogen bond acceptor strength of N-1 in 1,2,4-triazole rings was the main cause of the observed differences.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics