Recommanded Product: 2-Furoic hydrazide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis and anticancer activity of new ((furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole acyclic sugar derivatives.
New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems I (R1 = (S,S,R,R)-HOCH2(CHOH)3CH(OH) (A), (R,R,R)-HOCH2(CHOH)2CH(OH)) were synthesized by reaction of the corresponding hydrazide II with different aldose sugars. Heterocyclization of the formed hydrazones I afforded the derived acyclic nucleoside analogs III (R2 = (S,S,R,R)-HOCH2(CHOC(O)CH3)3CH(OH), (R,R,R)-H3C(O)COCH2(CHOC(O)CH3)2CH(OH)) possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the heterocyclization process. The anticancer activity of the synthesized compounds was studied against human liver carcinoma cell (HepG-2) and at human normal retina pigmented epithelium cells (RPE-1). High activities were revealed by compounds 4-(2-(furan-2-carbony!)hydrazinyl)-4-oxobutanoyl chloride, IV and (A) with IC50 values near to that of the reference drug doxorubicin.
This literature about this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazidehas given us a lot of inspiration, and I hope that the research on this compound(2-Furoic hydrazide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics