Analyzing the synthesis route of Benzo[d]isoxazol-3-amine

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo[d]isoxazol-3-amine,belong Benzisoxazole compound

As a common heterocyclic compound, it belong Benzisoxazole compound,Benzo[d]isoxazol-3-amine,36216-80-5,Molecular formula: C7H6N2O,mainly used in chemical industry, its synthesis route is as follows.,36216-80-5

To a solution of intermediate 3 (0.0025 mol) in isopropylether (5 ml) THF (1 ml) was added and the reaction mixture stirred at RT. Phenylisocyanaat (0.0050 mol) was added and the reaction mixture stirred overnight at RT. The precipitate was filtered off, washed with isopropylether and evaporated dried. The residue was further purified over reversed phase HPLC on a Xterra MS C18 column (3′. 5 Rm, 4.6 x 100 mm) with a flow rate of 1.6 ml/min (Elution conditions: three mobile phases (mobile phase A 95% e t..

25mM ammoniumacetate + 5% acetonitrile; mobile phase B: acetonitrile ; mobile phase C: methanol) were employed to run a gradient condition from 100 % A to 50% B and 50% C in 6.5 min., to 100 % B in 1 min, 100% B for 1 min. and re-equilibrate with 100 % A for 1.5 min.) yielding 0.010 g of compound 4 (yield of 5%, Melting Point 246C).

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo[d]isoxazol-3-amine,belong Benzisoxazole compound

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/89753; (2005); A2;,
Benzisoxazole – Wikipedia
Benzisoxazole – an overview | ScienceDirect Topics