The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 3,3-Dimethyl-2-oxobutanoic acid, 815-17-8, Name is 3,3-Dimethyl-2-oxobutanoic acid, SMILES is CC(C)(C)C(C(O)=O)=O, in an article , author is MAKOSZA, M, once mentioned of 815-17-8.
DOES NITROARYLATION OF PHENYLACETONITRILE PROCEED AS A PHASE-TRANSFER-CATALYZED PROCESS
The phase-transfer catalyzed reaction of phenylacetonitrile with 4-chloro-3-(trifluoromethyl)nitrobenzene produces 5-chloro-7-phenyl-4-(trifluoromethyl)benzisoxazole (5) not the nitroarylation product 3a as was reported by Durantini et al. (Durantini, E. N.; Chiacchiera, S. M.; Silber, J. J. J. Org. Chem. 1993, 58, 7115). The catalytic nitroarylation does not occur because the product 3a immediately forms a lipophilic carbanion which inhibits the catalytic process. The nitroarylation occurs under ion-pair extraction conditions when a stoichiometric amount of tetrabutylammonium bromide is used, whereas 2-phenylalkanenitriles are efficiently PTC nitroarylated. 4-Chloro-3-(trifluoromethyl)- and 2-chloro-5-(trifluoromethyl)nitrobenzenes enter vicarious nucleophilic substitution reactions with carbanions of chloromethyl p-tolyl sulfone. These results and formation of 5 show that carbanions add to these nitroarenes initially in positions occupied with hydrogen.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 815-17-8, you can contact me at any time and look forward to more communication. Recommanded Product: 3,3-Dimethyl-2-oxobutanoic acid.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics