The author of 《2-Alkylaminomethylbenzisoxazolin-3-ones》 were Bien, Irena; Domagalina, Eugenia. And the article was published in Acta Poloniae Pharmaceutica in 1981. Application of 65685-50-9 The author mentioned the following in the article:
3-Hydroxybenzisoxazole and its halo substituted derivatives were converted in the Mannich reaction into 16 new I (R = H, Cl, Br, R1 = H; R = H, R1 = 6-Cl, 6-R; R = Br, R1 = 7-Br; R2 = 4-morpholinyl, 1-piperidinyl, 4-methyl-1-piperazinyl). A similar reaction with piperazine gave 6 II; analogous compounds were obtained from 2,5-dimethylpiperazine. The yields varied from 41-90% for I almost quant. for II. In tests against Trichomonas vaginalis, I (R = Cl, R1 = H, R2 = 4-morpholinyl) revealed activity higher than that of metronidazole and tinidazole; it was also active against Rhabdilis strongyloides. In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Application of 65685-50-9)
5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.Application of 65685-50-9The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics