On June 28, 2012, Boss, Christoph; Brotschi, Christine; Heidmann, Bibia; Sifferlen, Thierry; Williams, Jodi T. published a patent.Computed Properties of 374554-89-9 The title of the patent was 3,8-Diazabicyclo[4.2.0]octane derivatives as orexin receptor antagonists and their preparation and use for the treatment of diseases. And the patent contained the following:
The invention relates to 3,8-Diazabicyclo[4.2.0]octane derivatives of formula cis-I, which are orexin receptor antagonists and which are useful in the treatment of diseases. Compounds of formula cis-I wherein Ar1is substituted Ph and substituted 5- to 6-membered heteroaryl; Ar2 is substituted 5- to 6-membered heteroaryl and substituted 8- to 10-membered bicyclic heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound cis-II was prepared by multistep procedure (procedure given). All the invention compounds were evaluated for their orexin receptor antagonistic activity. From the assay, it was determined that compound cis-II exhibited IC50 values of 1 nM and 5 nM towards OX1 and OX2, resp. The experimental process involved the reaction of 3-Chloro-6-fluorobenzo[d]isoxazole(cas: 374554-89-9).Computed Properties of 374554-89-9
The Article related to diazabicyclooctane preparation orexin receptor antagonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Computed Properties of 374554-89-9
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics