So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Abouzayed, Fatma I.; Emam, Sanaa M.; Abouel-Enein, Saeyda A. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Electric Literature of C5H6N2O2.They published the article 《Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand》 about this compound( cas:3326-71-4 ) in Journal of Molecular Structure. Keywords: transition metal Schiff terephthaldehyde furanamido hydrazide complex preparation ESR; thermal stability antioxidant transition metal Schiff terephthaldehyde furanamido hydrazide; anticancer transition metal Schiff terephthaldehyde furanamido hydrazide complex; frontier mol orbital transition metal Schiff terephthaldehyde furanamido hydrazide. We’ll tell you more about this compound (cas:3326-71-4).
Furo-(phenyldimethine)carbohydrazone (H2L) was prepared via the condensation reaction of 2-furoic acid hydrazide with terephthaldehyde by (2:1) molar ratio. Octahedral and square planar complexes were synthesized from the reaction of (H2L) ligand with chloride salts of Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) ions. All the chelates were structurally characterized by various anal. and spectral techniques. The stoichiometry of chelates was found to be 1:1, 1:2 and 1:3 (L:M) molar ratios to form sandwich, binuclear and trinuclear complexes, resp. All complexes were found to be non-electrolytic in nature on the basis of molar conductance values. The IR data showed that the ligand served as tetradentate in a neutral keto form. The ligand coordinated with all metal ions via oxygen atoms of carbonyl group and furan ring. The thermal properties of the ligand and its chelates were investigated utilizing thermogravimetry and reflected that Ru(III) complex has lower thermal stability than other complexes. X-ray diffraction spectra established nano-size for Ni(II) and Ru(III) complexes. The ESR result revealed axial symmetry with hyperfine structure for Cu(II) complex indicative of (2B1g) as a ground state. Some quantum parameters were reported in order to compare the reactivity of the compounds The biol. data indicated that all complexes have cytotoxic and antioxidant activity rather than the native ligand. Among all complexes, Ru(III) complex had excellent cytotoxic and antioxidant activity. This was due to its chem. structure and its nano-size.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Furoic hydrazide)Electric Literature of C5H6N2O2, illustrating the importance and wide applicability of this compound(3326-71-4).
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics